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ID 43824
JaLCDOI
フルテキストURL
Thumnail 65_1_1.pdf 389 KB
著者
Han, Xiao-Jian Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Tomizawa, Kazuhito Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Fujimura, Atsushi Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ohmori, Iori Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID
Nishiki, Tei-ichi Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID
Matsushita, Masayuki Department of Molecular and Cellular Physiology, School of Medicine, University of the Ryukyus
Matsui, Hideki Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
抄録
Mitochondria are important cellular organelles in most metabolic processes and have a highly dynamic nature, undergoing frequent fission and fusion. The dynamic balance between fission and fusion plays critical roles in mitochondrial functions. In recent studies, several large GTPases have been identified as key molecular factors in mitochondrial fission and fusion. Moreover, the posttranslational modifications of these large GTPases, including phosphorylation, ubiquitination and SUMOylation, have been shown to be involved in the regulation of mitochondrial dynamics. Neurons are particularly sensitive and vulnerable to any abnormalities in mitochondrial dynamics, due to their large energy demand and long extended processes. Emerging evidences have thus indicated a strong linkage between mitochondria and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and Huntington's disease. In this review, we will describe the regulation of mitochondrial dynamics and its role in neurodegenerative diseases.
キーワード
mitochondria
phosphorylation
ubiquitination
SUMOylation
neurodegeneration
Amo Type
Review
発行日
2011-02
出版物タイトル
Acta Medica Okayama
65巻
1号
出版者
Okayama University Medical School
開始ページ
1
終了ページ
10
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT