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ID 32113
JaLCDOI
フルテキストURL
著者
Ishii, Masamitsu Okayama University
Tomizawa, Kazuhito Okayama University
Matsushita, Masayuki Okayama University
Matsui, Hideki Okayama University Kaken ID publons researchmap
抄録

The central nervous system is highly plastic and has been shown to undergo both transient and chronic adaptive changes in response to environmental influences. The purpose of this study was to investigate the effect of hypergravic field on long-term potentiation (LTP) in the mouse hippocampus. Exposure of mice to 4G fields for 48 h had no effect on input-output coupling during extracellular stimulation of Schaffer collaterals and paired pulse facilitation, suggesting that the hypergravic exposure had no detrimental effect on basal neurotransmission in the hippocampus. However, the exposure to 4G fields for 48 h significantly induced LTP compared with the control mouse hippocampus. In contrast, no significant changes of late-phase LTP (L-LTP) were found in the hippocampi of mice exposed to the hypergravic field. Exposure of mice to 4G fields for 48 h enhanced AMPA receptor phosphorylation but not cyclic AMP-responsive element binding protein (CREB) phosphorylation. These results suggest that exposure to hyperdynamic fields influences the synaptic plasticity in the hippocampus.

キーワード
long-term potentiation (LTP)
AMPA receptor
cyclic AMP-responsive element binding protein (CREB)
plasticity
synapse
Amo Type
Article
発行日
2004-06
出版物タイトル
Acta Medica Okayama
58巻
3号
出版者
Okayama University Medical School
開始ページ
143
終了ページ
149
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT