フルテキストURL GRP_8159072.pdf
著者 Iwamuro, Masaya| Aoyama, Yuki| Suzuki, Seiyuu| Kobayashi, Sayo| Toyokawa, Tatsuya| Moritou, Yuki| Hori, Shinichiro| Matsueda, Kazuhiro| Yoshioka, Masao| Tanaka, Takehiro| Okada, Hiroyuki|
発行日 2019-09-08
出版物タイトル Gastroenterology Research and Practice
出版者 Hindawi
開始ページ 8159072
ISSN 1687-6121
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 Copyright © 2019 Masaya Iwamuro et al.
論文のバージョン publisher
PubMed ID 31582972
DOI 10.1155/2019/8159072
Web of Science KeyUT 000487588000001
関連URL isVersionOf https://doi.org/10.1016/bs.aiip.2019.01.001
JaLCDOI 10.18926/AMO/32203
フルテキストURL fulltext.pdf
著者 Matsueda, Kazuhiro| Yamada, Gotaro| Tsuji, Takao|
抄録 <p>In order to clarify difference of the mucosal immunity in various sites of normal large and small intestines, we studied the population of lymphocyte subsets and immunoglobulin (Ig)-containing cells in situ in biopsy specimens taken from various sites (ascending colon, sigmoid colon and rectum) of the large intestine and from the duodenum using an immunohistochemical method. Monoclonal antibodies against pan-T (Leu 1), cytotoxic/suppressor T (Leu2a), helper/inducer T (Leu3a), suppressor T (Leu15) and natural killer/K (Leu7) cells, and polyclonal antibodies to human IgG, IgA and IgM were used. In the duodenum, intraepithelial lymphocytes (IELs) were more prominent than in the large intestine. Immunoelectron microscopic observation revealed that some Leu2a+ IELs possessed pseudopods extending into intestinal epithelial cells, indicating that some IELs belong to the cytotoxic T cell subset. Leu7+ IELs were scarcely observed and Leu7+/Leu1+ ratio was higher in the large intestine than in the duodenum. Furthermore, the number of Leu7+ cells were more in the distal than the proximal colon. In the lamina propria Ig-containing cells tended to be fewer in the rectum than in the duodenum and the proximal colon. Our findings may suggest the variation of local immune responses and the difference of assigned immunological functions among the various sites of the intestines.</p>
キーワード cytotoxic T cell subsets anti-Leu7(NK/K cells) immunoglobulin-containing cells intestinal mucosa
Amo Type Article
発行日 1991-06
出版物タイトル Acta Medica Okayama
45巻
3号
出版者 Okayama University Medical School
開始ページ 161
終了ページ 169
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1891975
Web of Science KeyUT A1991FV15000006