JaLCDOI 10.18926/AMO/31580
フルテキストURL fulltext.pdf
著者 Akita, Masahiko| Mizuno, Kuniharu| Matsubara, Akira| Nakano, Kazumasa| Kurono, Masayasu|
抄録 <p>In order to clarify the mechanism of retinal tissue damage in diabetes mellitus, the effects of the inhibition of aldose reductase on the pathologic changes in the retina of streptozotocin-induced diabetic (STZ-diabetic) rats were examined histologically and histochemically. The STZ-diabetic animals were maintained with and without peroral administration of an aldose reductase inhibitor, SNK-860, and their retinas were examined microscopically after 12 months. Several abnormal changes observed; folding and edema in the retina, loss of pericytes in the retinal capillary walls, and thickening of basement membranes in the retinal capillaries, were significantly inhibited by SNK-860. Some of these changes were similar to those that had been previously noted in diabetic and galactosemic rats. These data suggest that the enhanced polyol metabolism may be involved in the diabetic changes of the retina.</p>
キーワード streptozotocim diabetes mellitus aldose reductase Inhibitor snk-860 retinopathy
Amo Type Article
発行日 1993-10
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 299
終了ページ 304
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8273453
Web of Science KeyUT A1993ME47100002