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ID 47013
JaLCDOI
フルテキストURL
著者
Wang, Lei Department of Urology, Peking University People's Hospital
Kaku, Haruki Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Huang, Peng Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Xu, Kexin Department of Urology, Peking University People's Hospital
Yang, Kai Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University
Zhang, Jiheng Department of Urology, Peking University School of Oncology, Beijing Cancer Hospital & Institute
Li, Ming Department of Urology, Peking University School of Oncology, Beijing Cancer Hospital & Institute
Xie, Liping Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University
Wang, Xiaofeng Department of Urology, Peking University People's Hospital
Sakai, Akiko Department of Molecular Genetics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Watanabe, Masami Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nasu, Yasutomo Research and Develop Center for Advanced Clinical Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Shimizu, Kenji Department of Molecular Genetics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 科研費研究者番号
Kumon, Hiromi Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Na, Yanqun Department of Urology, Peking University People's Hospital
抄録
Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of WRN Leu1074Phe (rs1801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN Leu1074Phe was genotyped by using a Snapshot assay. The results showed that WRN Leu1074Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR=0.58, 95%CI:0.35-0.97, p=0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <_ 72 yr (OR=0.27, 95%CI:0.12-0.61, p=0.002) and in patients with localized diseases (OR=0.36, 95%CI:0.19-0.70, p=0.003). However, no statistically significant difference was found in the subgroup with age >72 yr or in patients with advanced diseases. We concluded that the genetic variant Leu1074Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects.
キーワード
polymorphism
prostatic neoplasms
single nucleotide
susceptibility
WRN
Amo Type
Original Article
発行日
2011-10
出版物タイトル
Acta Medica Okayama
65巻
5号
出版者
Okayama University Medical School
開始ページ
315
終了ページ
323
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT