JaLCDOI 10.18926/AMO/54001
フルテキストURL 70_1_31.pdf
著者 Hanada, Takae| Kanamitsu, Kiichiro| Chayama, Kosuke| Miyamura, Takako| Kanazawa, Yui| Muraoka, Michiko| Washio, Kana| Imada, Masahide| Kageyama, Misao| Takeuchi, Akihito| Tamai, Kei| Oda, Megumi| Shimada, Akira|
抄録 The treatment of patients with congenital leukemia is difficult and often results in a poor prognosis. We present here the case of a female child with congenital acute myeloid leukemia (AML) with t(8 ; 16) (p11 ; p13) who received chemotherapy and survived for more than 10 years without relapse. A novel MOZ-CBP chimera was found in her diagnostic sample. Although adult AML patients with MOZ-CBP have mainly been reported as having therapy-related AML and showed poor prognoses, the present case supports the idea that AML with MOZ-CBP in the pediatric population might show better prognoses.
キーワード congenital leukemia AML t(8 ; 16)(p11 ; p13) MOZ-CBP
Amo Type Original Article
発行日 2016-02
出版物タイトル Acta Medica Okayama
70巻
1号
出版者 Okayama University Medical School
開始ページ 31
終了ページ 35
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26899607
Web of Science KeyUT 000371288700004
JaLCDOI 10.18926/AMO/51066
フルテキストURL 67_4_219.pdf
著者 Maruyama, Hidehiko| Nakamura, Makoto| Yonemoto, Naohiro| Kageyama, Misao|
抄録 Cholestasis and thrombocytopenia are complications that affect infants born small for gestational age (SGA). In SGA infants, other vital organs develop at the expense of the liver, and the thrombopoietin produced by the liver is low, often resulting in cholestasis. We hypothesized that thrombocytopenia at birth can be used to predict cholestasis in very-low-birth-weight infants (VLBWIs) with SGA. This retrospective cohort study enrolled VLBWIs with SGA admitted to a tertiary neonatal intensive care unit. A platelet cutoff value predictive of cholestasis was determined using receiver operating characteristic analysis. Multivariate logistic regression analysis was performed to evaluate the platelet cutoff value, and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Regarding the onset of cholestasis, survival analysis was performed by calculating the adjusted hazard ratios (HRs) and 95% CIs. A total of 87 infants were evaluated, and the platelet cutoff value was determined as 88×10(3) cells/μl. The adjusted OR for this platelet cutoff value was 10.52 (95% CI 2.26-55.93, p=0.003), and the adjusted HR was 7.76 (95% CI 2.51-23.50, p=0.0006). Thrombocytopenia is a useful predictor for cholestasis in VLBWIs with SGA.
キーワード cholestasis platelet small for gestational age thrombocytopenia very low birth weight
Amo Type Original Article
発行日 2013-08
出版物タイトル Acta Medica Okayama
67巻
4号
出版者 Okayama University Medical School
開始ページ 219
終了ページ 225
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23970320
Web of Sience KeyUT 000323470100003
JaLCDOI 10.18926/AMO/32809
フルテキストURL fulltext.pdf
著者 Kunii, Yuko| Kamada, Masahiro| Ohtsuki, Shinichi| Araki, Tohru| Kataoka, Kohichi| Kageyama, Misao| Nakagawa, Naomi| Seino, Yoshiki|
抄録 <p>This study was designed to explore whether it was possible to evaluate the severity of VSD, PDA, and ASD by measuring brain natriuretic peptide (BNP) levels. We also investigated normal BNP levels in children to provide a baseline for our study. We measured BNP levels in 253 normal children, including 11 normal neonates, and in 91 VSD patients, 29 PDA patients, and 34 ASD patients. BNP levels showed no age-related differences in normal children (the mean value: 5.3 +/- 3.8 pg/ml). In the healthy neonates, BNP levels rose from 10.4 +/- 11.9 pg/ml in cord blood to 118.8 +/- 83.2 pg/ml on day 0, then fell to 15.3 +/- 7.8 pg/ml by day 7. In VSD and PDA patients, BNP levels correlated significantly with Qp/Qs, LVEDV, and peak RVP/LVP. In ASD patients, BNP levels correlated with Qp/Qs and RVEDV. Especially, in VSD patients, as an index corresponding to 1.5-2.0 of the Qp/Qs ratio, BNP levels of 20-35 pg/ml were found to be best with regard to both sensitivity and specificity. In the healthy neonates, BNP levels changed rapidly after birth. In VSD, PDA, and ASD patients, BNP levels were well-correlated with the severity of the disease. Especially, in VSD patients, it that appears BNP levels may be useful in evaluating surgical indications, with 20-35 pg/ml levels being the appropriate cut-off value.</p>
キーワード brain natriuretic peptide congenital heart disease ventricular volume overload
Amo Type Article
発行日 2003-08
出版物タイトル Acta Medica Okayama
57巻
4号
出版者 Okayama University Medical School
開始ページ 191
終了ページ 197
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 14627071
Web of Science KeyUT 000184987100005