JaLCDOI 10.18926/AMO/31860
フルテキストURL fulltext.pdf
著者 Kaihara, Masanobu| Nakamura, Yoshio| Sugimoto, Taro| Uchida, Haruhito A.| Norii, Hisanao| Hanayama, Yoshihisa| Makino, Hirofumi|
抄録 <p>We investigated the impact of olmesartan and temocapril on pancreatic islet beta-cells during the development of diabetes mellitus using Otsuka-Long-Evans-Tokushima Fatty (OLETF) rats. Four-week-old male OLETF rats were fed standard chow (untreated:n5), or chow containing either 0.005% olmesartan(n5) or 0.01% temocapril (n5) until being sacrificed at 35 weeks of age. Pancreas sections were double-stained with anti-insulin and anti-glucagon antibodies. The percent areas of beta-cells, alpha-cells and non-alpha-non-beta-cells were compared among groups. In untreated OLETF rats, the fasting plasma glucose (FPG) level was elevated at the 18th week and remained elevated until the 35th week. On the other hand, no significant elevation in FPG levels was observed in olmesartan- or temocapril-treated rats. Pancreatic islets from olmesartan-treated rats were significantly smaller in size as compared with those from untreated OLETF rats. Furthermore, the average area occupied by beta-cells as a fraction of the total area of an individual islet was significantly higher in olmesartan- or temocapril-treated rats than that in untreated OLETF rats. Olmesartan and temocapril both prevented the development of hyperglycemia, possibly through the prevention of islet beta-cell loss in spontaneously diabetic OLETF rats.</p>
キーワード angiotensin II type-1 receptor blocker angiotensin converting enzyme inhibitor pancreas insulin secretion Type 2 diabetes mellitus
Amo Type Original Article
発行日 2009-02
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 35
終了ページ 42
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 19247421
Web of Science KeyUT 000263730300005