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ID 13823
Eprint ID
13823
フルテキストURL
Thumnail 106_117.pdf 3.83 MB
タイトル(別表記)
Insulin and leukotrienes production
著者
神坂 譲 岡山大学医学部第二内科学教室
抄録
Leukotrienes (LTs) are able to be produced by whole blood cells as well as polymorphonuclear leukocytes (PMN). To investigate whether these production rates were affected by insulin, LTs from PMN or whole blood cells were measured in 10 diabetic patients and 10 normal subjects using HPLC. The production rate of LTB4 from PMN was lower in diabetic patients than in normal subjects. When PMN were stimulated by CaI+glucose+insulin, the LTs productuin rate was significantly increased compared with that after stimulation by CaI alone in both normal subjects and diabetic patients. LTs production rats was significantly increased in a dose-dependent manner. 5-HETE release from PMN showed significant increase when PMN were stimulated by CaI+glucose+insulin. Comparing LTs release from CaI-stimulated whole blood with that after CaI+arachidonate stimulation. there was no significant difference in normal subjects. In diabetic subjects, LTC(4), LTD(4) and LTB(4) release stimulated by CaI+arachidonate was sinificantly higher than those stimulated by CaI alone. Comparing CaI with CaI+glucose+insulin as a stimulater or LTs release, the latter was significantly more potent than that of the former in both normal subjects and diabetic patients. Blood cells obthained from diabetic patients produced less LTs, but high concentrations of insulin combined with glucose restored LTs production. Production of LTC(4) was markedly promoted by these stimulants in diabetic patents. These findings regarding insulin action suggest mechanisms in the condition of hyperinsulinemia, i. e. they induce vasoconstriction and progression of atherogenesity, related to enfothelial cell damage, and smooth muscle cell proliferation.
キーワード
ロイコトリエン
インスリン
糖尿病
備考
原著
発行日
1994-02
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
106巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
117
終了ページ
129
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/106/1-2/106_1-2_117/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma