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ID 13835
Eprint ID
13835
フルテキストURL
Thumnail 106_145.pdf 1.6 MB
タイトル(別表記)
Clinicopatholgical studies on htpersensitivity pneumonitis : Cellular kinetics in bronchoalveolar lavage (BAL) fluid of the patients with hypersensitivity pneumonitis
著者
梶本 和宏 岡山大学医学部第二内科学教室
抄録
The cellular components of bronchoalveolar lavage (BAL) fluids from 26 patients with hypersensitivity pneumonitis were analyzed with regard to the period of antigen exposure before BAL procedure. In the early phase of antigen exposure BAL fluids contained increased neutrophils as well as lymphocytes while a low percentage of neutrophils and a prominent increase of lymphocytes were observed in chronic antigen exposure. Furthermore, the in-creased neutrophils decreased rapidly after cessation of antigen exposure while lymphocytes decreased gradually. In the BAL fluids of patients with summer-type hypersensitivity pneumonitis, CD4+ percentages and CD4/CD8 rations were significantly decreased, but CD8+ percentages significantly increased during antigen exposure compared with that in healthy controls. However, the actual CD4+ cell counts in BAL fluids significantly increased while CD4+ percentage decreased. Thus, CD4+ as well as CD8+ may play important roles in the pathogenesis of hypersensitivity pneumonitis. Soluble IL-2 receptor (sIL-2R) levels in BAL fluids and serum obtained from patients with hypersensitivity pneumonitis, especially serum sIL-2R during the active phase, were signifi-cantly higher than those of normal controls, indicating that the elevated sIL-2R level reflect-ed a highly activated immune response. In relation to pulmonary fuction, the lympocyte percentage showed a significant inverse correlation with % TLC and PaCO2, while neutrophil percentage showed significant correlation with % TLC and inverse correlation with FEV 1.0%. These reaults suggest that neutrophilia in BAL fluids affects bronchobronchiolar disorders during the early phase, and lympocytosis in BAL fluids regulates organic changes of the lung in hypersensitivity pneumonitis.
キーワード
過敏性肺臓炎
気管支肺胞洗浄法
Tリンパ球サブセット
吸入誘発試験
肺機能
備考
原著
発行日
1994-02
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
106巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
145
終了ページ
162
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/106/1-2/106_1-2_145/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma