著者 Higo, Hisao| Miyahara, Nobuaki| Taniguchi, Akihiko| Senoo, Satoru| Itano, Junko| Watanabe, Hiromi| Oda, Naohiro| Kayatani, Hiroe| Ichikawa, Hirohisa| Shibayama, Takuo| Kajimoto, Kazuhiro| Tanimoto, Yasushi| Kanehiro, Arihiko| Maeda, Yoshinobu| Kiura, Katsuyuki| OKAYAMA respiratory disease study group (ORDSG)|
キーワード Idiopathic pulmonary fibrosis High-resolution computed tomography Pirfenidone Forced vital capacity
備考 This fulltext is available in Feb. 2021.|
発行日 2020-02-23
出版物タイトル Respiratory Investigation
58巻
3号
出版者 Elsevier
開始ページ 185
終了ページ 189
ISSN 22125345
NCID AA12579673
資料タイプ 学術雑誌論文
言語 English
論文のバージョン author
PubMed ID 32102769
DOI 10.1016/j.resinv.2019.12.007
Web of Science KeyUT 000531841500009
関連URL isVersionOf https://doi.org/10.1016/j.resinv.2019.12.007
JaLCDOI 10.18926/AMO/31587
フルテキストURL fulltext.pdf
著者 Kitani, Hikaru| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Mifune, Takashi| Mitsunobu, Fumihiro| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Tanizaki, Yoshiro|
抄録 <p>Immunoallergological studies were carried out to clarify the differences between 24 patients with drug-induced asthma (DIA) and 240 with non-drug-induced asthma (non-DIA). The mean values of age, skin reaction to Candida albicans (C. albicans), serum IgE levels, specific IgE antibodies to house dust (HD) and C. albicans, bronchial sensitivity and leukotriene B4 (LTB4) synthesis from peripheral venous blood in patients with DIA were not significantly different from those in patients with non-DIA. In contrast, the frequency of positive skin reaction to HD and histamine release from peripheral basophils by anti-IgE were significantly lower in DIA than in non-DIA. These results agree with the reports that DIA was often observed in non-atopic asthma. But, the mean value of serum IgE was very high in DIA as well as in non-DIA. This result suggests that IgE mediated reaction in DIA is important. Furthermore, the proportion of neutrophils in bronchoalveolar lavage fluid (BALF) was significantly lower in DIA than in non-DIA. Our findings suggest that a decrease of intrapulmonary neutrophils might play an important role in the pathophysiology of DIA.</p>
キーワード drug allergy aspirin-induced asthma. LgE-mediated reacion chemical mediator bronchoalveolar lavage
Amo Type Article
発行日 1993-10
出版物タイトル Acta Medica Okayama
47巻
5号
出版者 Okayama University Medical School
開始ページ 317
終了ページ 321
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7505995
Web of Science KeyUT A1993ME47100005
JaLCDOI 10.18926/AMO/31578
フルテキストURL fulltext.pdf
著者 Mifune, Takashi| Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Kimura, Ikuro|
抄録 <p>The effects of long-term glucocorticoid therapy on chemical mediator and cellular reaction in the airways were examined in 69 patients with bronchial asthma. The histamine release induced by Ca ionophore A23187 from cells in the bronchoalveolar lavage (BAL) fluid of atopic asthmatics was significantly lower in the subgroup with steroid-dependent intractable asthma (SDIA) than in non-SDIA patients (p &#60; 0.05). In contrast, histamine release in nonatopic SDIA patients did not differ from nonatopic non-SDIA patients. The release of leukotriene C4 (LTC4) was significantly lower in atopic patients with SDIA (p &#60; 0.02). However, there was no significant difference in LTC4 release between nonatopic patients with SDIA and without SDIA. The proportion of BAL lymphocytes was significantly lower in atopic patients with SDIA than in those without it (p &#60; 0.05), although there was no significant difference between the nonatopic patients with and without SDIA. These results show that glucocorticoids affect humoral and cellular events in the airways of atopic asthmatics more than in those of nonatopic asthmatics.</p>
キーワード histamine leukotrienes BAL cells intractable asthma glucocorticoids
Amo Type Article
発行日 1993-10
出版物タイトル Acta Medica Okayama
47巻
5号
出版者 Okayama University Medical School
開始ページ 323
終了ページ 328
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7505996
Web of Science KeyUT A1993ME47100006