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ID 55301
フルテキストURL
著者
Itoh, Hideshi Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ichiba, Shing Department of Community and Emergency Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ujike, Yoshihito Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Douguchi, Takuma
Kasahara, Shingo Department of Cardiovascular Surgery, Okayama University Hospital
Arai, Sadahiko Department of Cardiovascular Surgery, Okayama University Hospital
Sano, Shunji Department of Cardiovascular Surgery, Okayama University Hospital
抄録
OBJECT:  We compared the clinical effectiveness and biocompatibility of poly-2-methoxyethyl acrylate (PMEA)-coated and heparin-coated cardiopulmonary bypass (CPB) circuits in a prospective pediatric trial.  METHODS:  Infants randomly received heparin-coated (n=7) or PMEA-coated (n=7) circuits in elective pediatric cardiac surgery with CPB for ventricular septum defects. Clinical and hematologic variables, respiratory indices and hemodynamic changes were analyzed perioperatively.  RESULTS:  Demographic and clinical variables were similar in both groups. Leukocyte counts were significantly lower 5 minutes after CPB in the PMEA group than the heparin group. Hemodynamic data showed that PMEA caused hypotension within 5 minutes of CPB. The respiratory index was significantly higher immediately after CPB and 1 hour after transfer to the intensive care unit (ICU) in the PMEA group, as were levels of C-reactive protein 24 hours after transfer to the ICU.  CONCLUSION:  Our study shows that PMEA-coated circuits, unlike heparin-coated circuits, cause transient leukopenia during pediatric CPB and, perhaps, systemic inflammatory respiratory syndrome after pediatric CPB.
キーワード
PMEA coating
cardiopulmonary bypass
heparin coating
pediatric
transient leukopenia
備考
学位審査副論文
発行日
2016-04
出版物タイトル
Perfusion
31巻
3号
出版者
Sage
開始ページ
247
終了ページ
254
ISSN
0267-6591
NCID
AA10674287
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン
author
PubMed ID
DOI
Web of Sience KeyUT
関連URL
https://doi.org/10.1177/0267659115598217
http://ousar.lib.okayama-u.ac.jp/54282