JaLCDOI 10.18926/AMO/31503
フルテキストURL fulltext.pdf
著者 Jin, Ze-Zhong| Neya, Toshiaki| Nakayama, Sosogu|
抄録 <p>The effects of caerulein on gastric motility in urethane-anesthetized rats were studied. Caerulein administered into the lateral cerebral ventricle (i.c.v.) and jugular vein (i.v.) caused predominantly an inhibitory effect on gastric motility but sometimes an excitatory or a biphasic effect. The inhibitory response was reduced after vagotomy and/or splanchnicotomy, or after guanethidine. The remaining inhibitory response was abolished by tetrodotoxin, but was resistant to atropine and guanethidine. The excitatory response was abolished by atropine. Discharges of the gastric branch of the vagus nerve were decreased by i.v. injection of caerulein but increased by i.c.v. injection, whereas those of the splanchnic nerve were increased by both i.v. and i.c.v. injection. These results suggest that caerulein causes an inhibition of gastric motility by centrally stimulating vagal non-adrenergic inhibitory nerves and splanchnic adrenergic nerves and inhibiting vagal cholinergic nerves, and by peripherally stimulating non-adrenergic inhibitory neurons of the myenteric plexus. This peptide causes an excitation by stimulating cholinergic neurons of the myenteric plexus.</p>
キーワード caerulein gastrointestinal hormones gastric motility autonomic nerves myenteric plexus
Amo Type Article
発行日 1985-12
出版物タイトル Acta Medica Okayama
39巻
6号
出版者 Okayama University Medical School
開始ページ 431
終了ページ 440
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 4091039
Web of Sience KeyUT A1985AWT4000002