JaLCDOI 10.18926/AMO/32021
フルテキストURL fulltext.pdf
著者 Zamolo, Gordana| Gruber, Franjo| Cabrijan, Leo| Micovic, Vladimir| Iternicka, Zlatko| Jonjic, Nives|
抄録 <p>Eighty-eight cases of cutaneous melanoma (CM) were analyzed in order to elucidate the relationship between thickness, angiogenesis, and prognosis. The thickness of the tumor was measured according to the Breslow method, and the microvessels were identified by an immunohistochemical study using anti-factor VIII monoclonal antibody on specimens from 40 patients with superficial spreading melanoma (SSM), and 48 with nodular type (NM). Microvessels were counted in the area of highest density. The overall survival and disease-free period were analyzed retrospectively. The proportion of patients with thicker CMs (&#62; 1.5 mm) increased with age in both sexes. Mean vascular count was statistically significant different only between thinner and thicker tumors in the SSM group (P &#60; 0.05). Prognosis was correlated with the thickness of CM (P = 0.0002), mean vascular count alone (P = 0.004), mean vascular count in association with CM thickness less than 1.5 mm (P = 0.0005), and with mean vascular count in NM (P = 0.02). These findings suggest that increasing microvessel density indicates a worsening prognosis.</p>
キーワード cutaneous melanoma anigiogenesis thickness prognosis
Amo Type Article
発行日 2001-11
出版物タイトル Acta Medica Okayama
55巻
5号
出版者 Okayama University Medical School
開始ページ 289
終了ページ 293
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 11688952
Web of Sience KeyUT 000171635400005