JaLCDOI 10.18926/AMO/31927
フルテキストURL fulltext.pdf
著者 Koide, Norio| Ukida, Minoru| Kondo, Hideaki| Jitoku, Michihiro| Ono, Ryosaku| Tanabe, Takayoshi| Nagashima, Hideo|
抄録 The amino-terminal peptides of type III procollagen (PIIIP) in the urine of 40 patients with various liver diseases were determined with a commercial radioimmunoassay kit. The level of urinary PIIIP (uPIIIP) was correlated well with serum PIIIP (sPIIIP) in 9 patients, the coefficient of correlation being r = 0.836 (p less than 0.01) and the regression line being y = 1.42x + 24. Urinary PIIIP consisted of at least 4 different molecular species with molecular weights of 49 k, 18 k, 10 k and 4.6 k as estimated by column chromatography on Sephadex G-100. Furthermore. uPIIIP was found to be significantly elevated in acute hepatitis, chronic hepatitis, liver cirrhosis, hepatocellular carcinoma and other liver diseases, in which the elevation of sPIIIP has been reported by others. The mean values +/- standard deviations of uPIIIP were 44.0 +/- 32.0, 60.4 +/- 32.0, 62.0 +/- 46.5, 53.0 +/- 27.1 and 48.1 +/- 22.8 ng/ml for the respective liver diseases, and 13.2 +/- 4.5 for the non-hepatic disease group.
キーワード type III collagen amino-terminal peptide urinary peptide molecular species lever diseases
Amo Type Article
発行日 1986-10
出版物タイトル Acta Medica Okayama
40巻
5号
出版者 Okayama University Medical School
開始ページ 243
終了ページ 247
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3788664
Web of Sience KeyUT A1986E557800002
JaLCDOI 10.18926/AMO/31907
フルテキストURL fulltext.pdf
著者 Jitoku, Michihiro| Koide, Norio| Nagashima, Hideo|
抄録 We applied a modified enzyme-linked immunosorbent assay (ELISA) for the measurement of human plasma fibronectin and determined the level of plasma fibronectin in 90 patients with various liver diseases and 10 normal subjects. Diagnoses were made by liver biopsy under peritoneoscopy. Plasma fibronectin was significantly decreased in liver cirrhosis patients, but not in acute hepatitis or chronic hepatitis patients. Decreased plasma fibronectin was correlated poorly with 18 laboratory tests, including liver function tests, and inflammatory marker determinations performed prior to peritoneoscopy. A correlation was found between the decreased plasma fibronectin and the severity of fibrotic, inflammatory and necrotic changes of the liver. These results suggested that the level of plasma fibronectin may reflect the severity of tissue injury resulting from chronic liver diseases.
キーワード plasma fibronectin liver diseases liver biopsy
Amo Type Article
発行日 1986-08
出版物タイトル Acta Medica Okayama
40巻
4号
出版者 Okayama University Medical School
開始ページ 189
終了ページ 194
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3766203
Web of Sience KeyUT A1986D870500002