JaLCDOI 10.18926/AMO/48263
フルテキストURL 66_2_131.pdf.pdf
著者 Jia, Lizhong| Kiryu, Shigeru| Watadani, Takeyuki| Akai, Hiroyuki| Yamashita, Hideomi| Akahane, Masaaki| Ohtomo, Kuni|
抄録 Patients with hepatocellular carcinoma (HCC) complicated by portal vein tumor thrombus (PVTT) have an extremely poor prognosis. It is important to select adequate therapeutic options based on reliable prognostic factors using imaging studies and clinical data. Prognostic factors were analyzed in patients with HCC with PVTT in the first branch or main trunk of the portal vein. From 2000 to 2007, 107 consecutive patients with HCC with PVTT in the major portal vein were reviewed, and diagnostic images and clinical characteristics were retrospectively observed. Thirty-eight possible prognostic factors for survival were analyzed by the log-rank test and multivariate analysis using Coxʼs proportional hazards model. Median overall survival was 14 months following PVTT diagnosis. Survival rates at 6 months, 1, 2, and 3 years were 72.1%, 52.6%, 32.6%, and 29.6%, respectively. Independent prognostic factors for longer survival included:patient age <65 years, Child-Pugh classification A/B, PVTT treatment, accumulation of Lipiodol in the PVTT after TACE, initial radical treatment for HCC, HCC located in a single lobe of the liver, and no invasion of HCC to the hepatic vein or bile duct. Survival was associated with liver function, tumor extension, and treatment for HCC and PVTT.
キーワード hepatocellular carcinoma portal vein tumor thrombus prognostic factors
Amo Type Original Article
発行日 2012-04
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 131
終了ページ 141
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22525471
Web of Sience KeyUT 000303175300006