JaLCDOI 10.18926/AMO/31526
フルテキストURL fulltext.pdf
著者 Shimamura, Junnosuke| Taketa, Kazuhisa| Ide, Takero| Nakata, Kenichi| Nagashima, Hideo|
抄録 <p>Levels of plasma cyclic AMP, serum immunoreactive insulin (IRI), serum c-peptide immunoreactivity (CPR) and blood sugar (BS) were determined 0, 15, 30, 45 and 60 min after a glucagon injection (0.01 mg per kg body weight) in normal controls, patients with acute hepatitis and liver cirrhosis. Plasma cyclic AMP responses to glucagon in liver disease patients varied widely in peak value, and only in patients with fulminant hepatitis and decompensated liver cirrhosis with poor prognosis was the response suppressed. The peak response of BS was found significantly later in liver cirrhosis patients than in normal controls. IRI and CPR responses to glucagon were lower in acute hepatitis patients than in normal controls and liver cirrhosis patients. IRI levels and their sum were also lower in acute hepatitis patients, although CPR levels were not significantly different. Thus, the ratio of the sum of CPR from 0 to 60 min to that of IRI was significantly higher in acute hepatitis, indicating impaired pancreatic secretion of insulin to glucagon stimulation as well as increased uptake of insulin by the liver in acute hepatitis.</p>
キーワード liver diseases glucagon cyclic AMP immunoreactive insulin c-peptide immunoreactivity
Amo Type Article
発行日 1985-10
出版物タイトル Acta Medica Okayama
39巻
5号
出版者 Okayama University Medical School
開始ページ 385
終了ページ 396
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3000142
Web of Sience KeyUT A1985ATK7300005
JaLCDOI 10.18926/AMO/30548
フルテキストURL fulltext.pdf
著者 Ide, Takero| Taketa, Kazuhisa| Watanabe, Makoto| Ikeda, Satoru| Izumi, Masaki| Sokabe, Teruko| Kono, Hiroshi| Yamamoto, Yoshio|
抄録 <p>&lt;p&gt;The levels of HDL-cholesterol and gamma-glutamyltransferase in the sera of 17 patients with alcoholic liver injury were followed after abstinence and compared with those of 11 patients with acute non-alcoholic hepatitis. The activity of gamma-glutamyltransferase decreased in all cases irrespective of the type of liver injuries. The level of HDL-cholesterol also decreased in 11 of 17 cases with alcoholic liver injury. The other alcoholics, in whom HDL-cholesterol level increased or showed no definite change after withdrawal of alcohol, had severe and advanced liver injuries. In non-alcoholic hepatitis, the HDL-cholesterol level increased as normal liver functions were restored except for one case with cholestatic features. It was concluded that alcohol intake can increase HDL-cholesterol level even in the presence of a concomitantly induced hepatic lesion.&lt;/p&gt;</p>
キーワード alcoholic liver injury HDL-cholesterol ?-glutamy1-transferase.
Amo Type Article
発行日 1980-11
出版物タイトル Acta Medica Okayama
34巻
5号
出版者 Okayama University Medical School
開始ページ 293
終了ページ 299
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6108050
Web of Sience KeyUT A1980KT96800001