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ID 31950
JaLCDOI
フルテキストURL
Thumnail fulltext.pdf 1.63 MB
著者
Wu, Di Kagawa University
Miyamoto, Osamu Kagawa University, Kagawa
Shibuya, Sei Kagawa University
Okada, Maiko Kagawa University
Igawa, Hiroharu Kagawa University
Janjua, Najima A. Kagawa University
Norimatsu, Hiromichi Kagawa University
Itano, Toshifumi Kagawa University
抄録

Macrophages and microglia are implicated in spinal cord injury, but their precise role is not clear. In the present study, activation of these cells was examined in a spinal cord injury model using 2 different antibodies against ED1 clone and ionized calcium binding adaptor molecule 1 (Iba1). Activation was observed at 1, 4, 8, and 12 weeks after contusion injury and was compared with sham operated controls. Our results indicate that activation could be observed in both the dorsal funiculus and the ventral white matter area in the spinal cord at 5 mm rostral to the epicenter of injury. For both cells, there was a gradual increase in activation from 1-4 weeks, followed by down-regulation for up to 12 weeks. As a result, we could stain macrophages by ED1 and microglia by Iba1. We concluded that macrophages may play a role in the phagocytosis of denatured dendrites after spinal cord injury, while microglia may have some cooperative functions, as they were found scattered near the macrophages.

キーワード
macrophages
microglia
spinal cord injury
ED1
Iba1
Amo Type
Article
発行日
2005-08
出版物タイトル
Acta Medica Okayama
59巻
4号
出版者
Okayama University Medical School
開始ページ
121
終了ページ
127
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT