JaLCDOI 10.18926/AMO/31004
フルテキストURL fulltext.pdf
著者 Ichiyasu, Akira| Makino, Hirofumi|
抄録 <p>Isolated rat glomerular basement membrane was treated with elastase and observed by transmission electron microscopy. The treatment with elastase revealed the fundamental structure of the glomerular basement membrane quite clearly, and enabled the observation of a sieve structure within the glomerular basement membrane. This sieve structure may play a major role in the filtration of blood as well as in the production of urine. Treatment with antibody showed that the sieve was mainly constituted of type IV collagen.</p>
キーワード glomerular basement membrane enzymatic digestion meshwork structure type IV collagen elastase
Amo Type Article
発行日 1988-12
出版物タイトル Acta Medica Okayama
42巻
6号
出版者 Okayama University Medical School
開始ページ 317
終了ページ 325
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2467525
Web of Sience KeyUT A1988R743300003
JaLCDOI 10.18926/AMO/31729
フルテキストURL fulltext.pdf
著者 Ichiyasu, Akira| Takaoka, Michio| Makino, Hirofumi| Takahashi, Kayo| Ota, Zensuke|
抄録 <p>Rat kidney glomerular basement membrane (GBM) was isolated and digested with alpha-amylase and elastase. Electron microscopy revealed a meshwork structure composed of fibrils 3 nm in width. They appeared to be type IV collagen fibrils. We succeeded in clarifying a significant ultrastructural aspect of the GBM which had been unclear until now. The findings are consistent with our previously proposed GBM molecular sieve theory.</p>
キーワード type IV collagen glomerular basement membrane enzymatic digestion fibrillar ultrastructure
Amo Type Article
発行日 1987-08
出版物タイトル Acta Medica Okayama
41巻
4号
出版者 Okayama University Medical School
開始ページ 183
終了ページ 185
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3499055
Web of Sience KeyUT A1987J833200007