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Hashimoto, Tasuku Department of Psychiatry, Chiba University Graduate School of Medicine
Hashimoto, Kenji Department of Psychiatry, Chiba University Graduate School of Medicine
Matsuzaka, Daisuke Department of Psychiatry, Chiba University Graduate School of Medicine
Shimizu, Eiji Department of Psychiatry, Chiba University Graduate School of Medicine
Sekine, Yoshimoto Department of Psychiatry and Neurology, Hamamatsu University School of Medicine
Yoshiya, Inada Department of Psychiatry, Nagoya University Graduate School of Medicine
Iwata, Nakao Department of Psychiatry, Fujita Health University School of Medicine
Harano, Mutsuo Department of Neuropsychiatry, Kurume University School of Medicine
Komiyama, Tokutaro National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP)
Yamada, Mitsuhiko National Institute of Mental Health, NCNP
Sora, Ichiro Division of Psychobiology, Tohoku University Graduate School of Medicine
Ujike, Hiroshi Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry
Iyo, Masaomi Department of Psychiatry, Chiba University Graduate School of Medicine
Several lines of evidence suggest that oxidative stress plays a role in the mechanisms of action of methamphetamine (MAP) in the human brain. Given the role of glutathione S-transferases (GSTs) in the protection against oxidative stress, genes encoding the GSTs have been considered as candidates for association studies of MAP abuse. This study was undertaken to investigate the role of the functional polymorphism of GSTP1 gene exon 5 (Ile105Val) in the pathogenesis of MAP abuse. Genotyping for GSTP1 gene polymorphism exon 5 (Ile105Val) in 189 MAP abusers and 199 normal controls was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Association between GSTP1 gene polymorphism and clinical features (prognosis of psychosis (transient-type and prolonged-type), spontaneous relapse (positive and negative), and poly-substance abuse) of MAP abusers was evaluated. Significant differences in the frequency of both alleles (P = 0.026, odds ratio: 1.70, 95% confidence intervals (CI) 1.06-2.72) and genotypes (P = 0.029) between MAP abusers and controls were detected. In particular, a significant difference in both genotype frequency (P = 0.013) and allele frequency (P = 0.014, odds ratio: 1.84, 95% CI 1.13-2.97) between MAP abusers with psychosis (transient-type and prolonged-type) and controls was detected. Our findings suggest that the polymorphism (Ile 105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population.
genetic factor; polymorphism
Digital Object Identifer: 10.1002/ajmg.b.30164
Published with permission from the copyright holder. This is the author's copy, as published in American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, May 2005, Volume 135B, Issue 1, Pages 5-9.
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Copyright © 2005 Wiley-Liss, Inc. All rights reserved.
American Journal of Medical Genetics Part B, Neuropsychiatric Genetics
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