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ID 32982
フルテキストURL
著者
Moriyama, Yoshinori Department of Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University
Hayashi, Mitsuko Department of Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University
Yamada, Hiroshi Department of Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University
Yatsushiro, Shouki Department of Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University
Ishio, Shougo Department of Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University
Yamamoto, Akitsugu Department of Physiology, Kansai Medical University
抄録
Microvesicles in endocrine cells are the morphological and functional equivalent of neuronal synaptic vesicles. Microvesicles accumulate various neurotransmitters through a transmitter-specific vesicular transporter energized by vacuolar H+-ATPase. We found that mammalian pinealocytes, endocrine cells that synthesize and secrete melatonin, accumulate L-glutamate in their microvesicles and secrete it through exocytosis. Pinealocytes use L-glutamate as either a paracrine- or autocrine-like chemical transmitter in a receptor-mediated manner, resulting in inhibition of melatonin synthesis. In this article, we briefly describe the overall features of the microvesicle-mediated signal-transduction mechanism in the pineal gland and discuss the important role of acidic organelles in a novel regulatory mechanism for hormonal synthesis and secretion.
キーワード
V-ATPase
melatonin
L-glutamate
serotonin
paracrine
autocrine
pinealocyte
endocrine cell.
備考
Published with permission from the copyright holder. This is the institute's copy, as published in The Journal of Experimental Biology, January 2000, Volume 203, Issue 1, Pages 117-125.
Publisher URL:http://jeb.biologists.org/cgi/reprint/203/1/117
Copyright © 2000 The Company of Biologists Limited. All rights reserved.
発行日
2001-01
出版物タイトル
The Journal of Experimental Biology
203巻
1号
出版者
The Company of Biologists Limited
開始ページ
117
終了ページ
125
ISSN
0022-0949
NCID
AA00697490
資料タイプ
学術雑誌論文
言語
English
著作権者
The Company of Biologists Limited
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT
Submission Path
biology_general/9