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ID 30562
JaLCDOI
フルテキストURL
著者
Takaya, Yasumasa Okayama University
Ota, Zensuke Okayama University
Makino, Hirofumi Okayama University
Kida, Keiko Okayama University
Miyoshi, Akira Okayama University
Hiramatsu, Makoto Okayama University
Takahashi, Kayo Okayama University
Ofuji, Tadashi Okayama University
抄録
Isolated and purified glomerular basement membranes (GBM) of normal and aminonucleoside (PAN) nephrosis rats were observed by electron microscopy after negative staining. Although GBM of normal rats appeared as a molecular sieve with uniform pores, GBM of nephrotic rats showed enlargement and elongation of the pores. For an average of fifty pores, the long dimension was 40.4+/-10.7 A and the short dimension 13.8+/-3.6 A in nephrosis whereas the long dimension was 12.3+/-2.5 A and the short dimension 8.4+/-1.0 A in normal rats. Changes in the pores in GBM were thought to result in increased permeability of serum protein and hence proteinuria.
キーワード
gromerular basement membranc
aminonucleoside nephrosis
negative staining.
Amo Type
Brief Note
発行日
1980-02
出版物タイトル
Acta Medica Okayama
34巻
1号
出版者
Okayama University Medical School
開始ページ
67
終了ページ
70
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT