| JaLCDOI | 10.18926/AMO/31561 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Hamazaki, Heisuke| Kato, Tomohiro| Yunoki, Yasuhiro| Mori, Masanobu| Gochi, Akira| Mimura, Hisashi| Orita, Kunzo| |
| 抄録 | <p>To determine whether a relationship exists between DNA ploidy and the prognosis of hepatocellular carcinoma (HCC), flow cytometric DNA analysis was performed in paraffin-embedded specimens obtained from 44 patients with HCC who underwent hepatectomy. There were 26 diploid (59%) and 18 aneuploid (41%) tumors. No correlation was shown between DNA ploidy pattern and patient age, sex, liver cirrhosis, hepatitis B virus antigen and serum alpha-fetoprotein level. The ploidy pattern had no significant correlation with the presence of vascular invasion or intrahepatic metastasis. Only Edmondson's grade was well correlated with the ploidy pattern. We noted a significant correlation between survival rates and the presence of vascular invasion or intrahepatic metastasis (p < 0.05). In contrast, no significant correlation was found between DNA ploidy pattern and the prognosis of HCC. The results of this study indicate that DNA ploidy pattern may not be a useful indicator for the prognosis of HCCs after hepatic resection, unlike the results of gastric and colon cancers. </p> |
| キーワード | DNA ploidy pattern hepatocellular carcinoma hepatic resection prognosis |
| Amo Type | Article |
| 発行日 | 1993-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 47巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 413 |
| 終了ページ | 416 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 8128916 |
| Web of Sience KeyUT | A1993MP00700009 |