Okayama University Medical School Acta Medica Okayama 0386-300X 47 6 1993 An analysis of DNA ploidy pattern of hepatocellular carcinoma. 413 416 EN Heisuke Hamazaki Tomohiro Kato Yasuhiro Yunoki Masanobu Mori Akira Gochi Hisashi Mimura Kunzo Orita Article 10.18926/AMO/31561 <p>To determine whether a relationship exists between DNA ploidy and the prognosis of hepatocellular carcinoma (HCC), flow cytometric DNA analysis was performed in paraffin-embedded specimens obtained from 44 patients with HCC who underwent hepatectomy. There were 26 diploid (59%) and 18 aneuploid (41%) tumors. No correlation was shown between DNA ploidy pattern and patient age, sex, liver cirrhosis, hepatitis B virus antigen and serum alpha-fetoprotein level. The ploidy pattern had no significant correlation with the presence of vascular invasion or intrahepatic metastasis. Only Edmondson's grade was well correlated with the ploidy pattern. We noted a significant correlation between survival rates and the presence of vascular invasion or intrahepatic metastasis (p &#60; 0.05). In contrast, no significant correlation was found between DNA ploidy pattern and the prognosis of HCC. The results of this study indicate that DNA ploidy pattern may not be a useful indicator for the prognosis of HCCs after hepatic resection, unlike the results of gastric and colon cancers. </p> No potential conflict of interest relevant to this article was reported.