このエントリーをはてなブックマークに追加
ID 30755
JaLCDOI
フルテキストURL
著者
Taira, Naruto Okayama University Kaken ID
Doihara, Hiroyoshi Okayama University Kaken ID researchmap
Oota, Tetsuya Okayama University
Hara, Fumikata Okayama University
Shien, Tadahiko Okayama University ORCID Kaken ID publons
Takahashi, Hirotoshi Okayama University
Yoshitomi, Seiji Okayama University
Ishibe, Youichi Okayama University
Shimizu, Nobuyoshi Okayama University
抄録

Human esophageal cancers have been shown to express high levels of epidermal growth factor receptor (EGFR) and a relationship between high EGFR expression and local advance, the number of lymph node metastases, life expectancy, and sensitivity to chemo-radiotherapy has been demonstrated. We examined the use of gefitinib, an orally active EGFR-selective tyrosine kinase inhibitor, as a new strategy for treatment of esophageal carcinoma. The effects of gefitinib were evaluated in monotherapy and in combination with radiotherapy in human esophageal carcinoma cell lines. Gefitinib produced a dose-dependent inhibition of cellular proliferation in all of the 8 esophageal carcinoma cell lines examined, with IC50 values ranging from 5.7 microM to 36.9 microM. In combination, gefitinib and radiotherapy showed a synergistic effect in 2 human esophageal carcinoma cell lines and an additive effect in 5 cell lines. Western blotting demonstrated that gefitinib blocked activation of the EGFR-extracellular signal-regulated kinase (Erk) pathway and the EGFR-phosphoinositide-3 kinase (PI3K)-Akt pathway after irradiation. These results suggest that further evaluation of EGFR blockade as a treatment for esophageal cancer should be performed, and that radiotherapy combined with EGFR blockade may enhance the response of esophageal carcinoma to therapy.

キーワード
gefitinib
esophageal cancer
radiosensitivity
epidermal growth factor receptor
Amo Type
Article
発行日
2006-02
出版物タイトル
Acta Medica Okayama
60巻
1号
出版者
Okayama University Medical School
開始ページ
25
終了ページ
34
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT