JaLCDOI 10.18926/AMO/32205
フルテキストURL fulltext.pdf
著者 Shinozawa, Shinya| Gomita, Yutakata| Araki, Yasunori|
抄録 <p>&#60;P&#62;The tissue concentration of doxorubicin (adriamycin; ADM) and its major metabolite (aglycone I) was examined in mice pretreated with alpha-tocopherol (VE) or coenzyme Q10 (CoQ). In VE-pretreated group, the concentrations of aglycone I of the liver (1, 3 and 5 h after the administration), kidney (1 and 3h) and heart (3h) were significantly higher than those in the saline group. The clinical application of VE or CoQ concomitant with anti-tumor drugs especially ADM, requires caution.</p>
キーワード doxorubicin tissue concentration ?-tocopherol coenzymeQ10
Amo Type Article
発行日 1991-06
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 195
終了ページ 199
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1891979
Web of Science KeyUT A1991FV15000011