このエントリーをはてなブックマークに追加
ID 32879
JaLCDOI
フルテキストURL
著者
Umeda, Yuichi Ehime University
Amano, Manabu Okayama University
Suemaru, Katsuya Ehime University
Yamaguchi, Takumi Ehime University
Kitamura, Yoshihisa Okayama University Hospital
Gomita, Yutaka Okayama University Hospital
Kawasaki, Hiromu Okayama University
Araki, Hiroaki Ehime University
抄録

Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis induces hyperglycemia and serotonin (5-HT)2A receptor supersensitivity. In the present study, to investigate the effect of hyperglycemia on the function of 5-HT2A receptors, we compared the 5-HT2A receptor-mediated wet-dog shake responses in rats treated with adrenocorticotropic hormone (ACTH), dexamethasone and streptozotocin. ACTH (100 μg/rat per day, s.c.), dexamethasone (1 mg/kg per day, s.c.) and streptozotocin (60 mg/kg, i.p.) produced significant hyperglycemia at 14 days after the start of these treatments, and the hyperglycemia was most pronounced in the streptozotocin-treated rats. The wet-dog shake responses induced by (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a 5-HT2A receptor agonist, were significantly enhanced at 14 days after repeated treatment with ACTH and dexamethasone. However, streptozotocin-induced diabetes had no effect on the wet-dog shake responses. The results of the present study suggest that hyperglycemia is not strongly associated with the enhanced susceptibility of 5-HT2A receptors under the condition of hyperactivity of the HPA axis.

キーワード
hyperglycemia
ACTH
dexamethasone
streptozotocin
5-HT2A receptor
Amo Type
Original Article
発行日
2007-12
出版物タイトル
Acta Medica Okayama
61巻
6号
出版者
Okayama University Medical School
開始ページ
311
終了ページ
317
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT