JaLCDOI 10.18926/AMO/52893
フルテキストURL 68_5_255.pdf
著者 Esumi, Satoru| Kawasaki, Yoichi| Gomita, Yutaka| Kitamura, Yoshihisa| Sendo, Toshiaki|
抄録 Motivation incorporates several psychological aspects that produce reward-related and learning behaviors. Although reward-related behavior is reported to be mediated by the dopaminergic reward pathway, the involvement of dopaminergic systems in motivated behavior has not been fully clarified. Several experimental methodologies for motivational behavior have been reported, but pharmacological characteristics seem to vary among these methodologies. In this review, we attempt to summarize three main concepts:(1) the relationship of dopamine neuron physiology with motivated behavior, (2) the pharmacological characteristics of the runway intracranial self-stimulation model, and (3) the behavioral distinction of disparate motivated behaviors.
キーワード motivation reward dopamine operant behavior intracranial self-stimulation
Amo Type Review
発行日 2014-10
出版物タイトル Acta Medica Okayama
68巻
5号
出版者 Okayama University Medical School
開始ページ 255
終了ページ 262
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25338481
Web of Sience KeyUT 000343269300001
著者 Esumi, Satoru| Sagara, Hidenori| Nakamoto, Akihiko| Kawasaki, Yoichi| Gomita, Yutaka| Sendo, Toshiaki|
発行日 2013-04-15
出版物タイトル Behavioural Brain Research
243巻
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/40501
フルテキストURL 64_5_267.pdf
著者 Sagara, Hidenori| Sendo, Toshiaki| Gomita, Yutaka|
抄録 In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation.
キーワード intracranial self-stimulation behavior motivational effect methamphetamine nicotine
Amo Type Review
発行日 2010-10
出版物タイトル Acta Medica Okayama
64巻
5号
出版者 Okayama University Medical School
開始ページ 267
終了ページ 275
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2010 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 20975759
Web of Sience KeyUT 000283563300001
JaLCDOI 10.18926/AMO/40129
フルテキストURL 64_4_219.pdf
著者 Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa|
抄録 We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.
キーワード ACTH imipramine lithium proliferation Ki-67
Amo Type Original Article
発行日 2010-08
出版物タイトル Acta Medica Okayama
64巻
4号
出版者 Okayama University Medical School
開始ページ 219
終了ページ 223
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 20802538
Web of Sience KeyUT 000281384400002
著者 Kitamura, Yoshihisa| Akiyama, Kozue| Kitagawa, Kouhei| Shibata, Kazuhiko| Kawasaki, Hiromu| Suemaru, Katsuya| Araki, Hiroaki| Sendo, Toshiaki| Gomita, Yutaka|
発行日 2008-05-20
出版物タイトル Pharmacology Biochemistry and Behavior
89巻
3号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32879
フルテキストURL fulltext.pdf
著者 Umeda, Yuichi| Amano, Manabu| Suemaru, Katsuya| Yamaguchi, Takumi| Kitamura, Yoshihisa| Gomita, Yutaka| Kawasaki, Hiromu| Araki, Hiroaki|
抄録 <p>Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis induces hyperglycemia and serotonin (5-HT)2A receptor supersensitivity. In the present study, to investigate the effect of hyperglycemia on the function of 5-HT2A receptors, we compared the 5-HT2A receptor-mediated wet-dog shake responses in rats treated with adrenocorticotropic hormone (ACTH), dexamethasone and streptozotocin. ACTH (100 &#956;g/rat per day, s.c.), dexamethasone (1 mg/kg per day, s.c.) and streptozotocin (60 mg/kg, i.p.) produced significant hyperglycemia at 14 days after the start of these treatments, and the hyperglycemia was most pronounced in the streptozotocin-treated rats. The wet-dog shake responses induced by (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a 5-HT2A receptor agonist, were significantly enhanced at 14 days after repeated treatment with ACTH and dexamethasone. However, streptozotocin-induced diabetes had no effect on the wet-dog shake responses. The results of the present study suggest that hyperglycemia is not strongly associated with the enhanced susceptibility of 5-HT2A receptors under the condition of hyperactivity of the HPA axis.</p>
キーワード hyperglycemia ACTH dexamethasone streptozotocin 5-HT2A receptor
Amo Type Original Article
発行日 2007-12
出版物タイトル Acta Medica Okayama
61巻
6号
出版者 Okayama University Medical School
開始ページ 311
終了ページ 317
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 18183075
Web of Sience KeyUT 000251943800001
JaLCDOI 10.18926/AMO/32870
フルテキストURL fulltext.pdf
著者 Amano, Manabu| Suemaru, Katsuya| Cui, Ranji| Umeda, Yuichi| Li, Bingjin| Gomita, Yutaka| Kawasaki, Hiromu| Araki, Hiroaki|
抄録 Several epidemiological and clinical studies have indicated that the prevalence of psychiatric disorders is higher in diabetic patients than in the general population. In the present studies, we examined the behavioral changes in streptozotocin-induced diabetic rats, and investigated the effects of physical and psychological stress on the hippocampal BDNF levels and on the serotonin 2A (5-HT2A) receptor-mediated wet-dog shake responses. The streptozotocin (60 mg/kg, i.p.)-induced diabetes had no significant effects on the immobility time in the forced swim test or on locomotor activity in the open-field test. Moreover, there was no significant difference in the wet-dog shake responses induced by DOI, a 5-HT2A receptor agonist, between nondiabetic and diabetic rats. Five-day exposure to physical (electric footshock) and psychological (non-footshock) stress had no signifi cant effect on the hippocampal BDNF level in diabetic or nondiabetic rats. The 2 types of stress had no significant effect on the DOI-induced wet-dog shake responses in nondiabetic rats. In diabetic rats, the repeated exposure to physical stress markedly increased the DOI-induced wet-dog shake responses, but the repeated exposure to psychological stress had no effect. These results suggest that exposure to physical stress augmented the susceptibility to the wet-dog shake responses to 5-HT2A receptor stimulation in streptozotocin-induced diabetic rats.
キーワード streptozotocin physical stress psychological stress 5-HT2A receptor wet-dog shake
Amo Type Original Article
発行日 2007-08
出版物タイトル Acta Medica Okayama
61巻
4号
出版者 Okayama University Medical School
開始ページ 205
終了ページ 212
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 17726509
Web of Sience KeyUT 000248957100004
JaLCDOI 10.18926/AMO/32836
フルテキストURL fulltext.pdf
著者 Gomita, Yutaka| Ichimaru, Yasuyuki| Moriyama, Minehiro| Araki, Hiroaki| Futagami, Koujiro|
抄録 <p>In considering the characteristics of the action of anxiolytic drugs and their mechanism in the brain, it may be necessary not only to study the behavioral pharmacology but also to perform brain site research. In the present study, the action of anxiolytic drugs was examined with respect to various behaviors that were induced by stimulating the brain areas related to emotions such as reward (pleasure) or aversion in rats. First, the low rate of response in lateral hypothalamic self-stimulation behavior was induced by schedules of low current brain stimulation, variable interval (VI) and differential reinforcement of low rate (DRL). Anxiolytic drugs such as benzodiazepines facilitated these low-rate responses. The drug susceptibility was highest in the low current stimulation, lower in the VI stimulation, and lowest in the DRL stimulation schedules. Furthermore, it was found by the auto-titration method in intracranial self-stimulation behavior that anxiolytic drugs decreased the threshold of stimulation reward. Second, it was recognized using the decremental lever pressing (DLP) paradigm that anxiolytic drugs increased the threshold of aversive stimulation of mesencephalic dorsal central gray (DCG), and this increasing effect of the drug was antagonized by GABA receptor blockers such as biccuculline. Finally, it was examined whether or not the conflict situation is established by combining brain stimulation reward and aversion, such as foot-shock or DCG stimulation. As a result, the conflict behavior was established by combining not only the brain stimulation reward and foot-shock aversion, but also the brain stimulation reward and DCG stimulation aversion. Further anxiolytic drugs exhibited anti-conflict action in both situations. The susceptibility of anxiolytic drugs was higher with respect to the conflict behavior induced by intracranial reward and aversion than to that induced by the conventional method based on milk reward and foot-shock aversion. These results suggest that behavioral methods using brain stimulation can examine the mechanisms of direct drug action at the brain stimulation site. Indeed, in the present brain stimulation behavioral study, anxiolytic drugs such as benzodiazepines increased the stimulation threshold in lateral hypothalamic self-stimulation and inhibited the DCG aversive stimulation, thus resulting in an anticonflict action of the drugs.</p>
キーワード anxiolytic drugs lateral hypothalamic self-stimulation escape behavior induced by mesencephalic dorsal central gray stimulation conflict behavior rats
Amo Type Review
発行日 2003-06
出版物タイトル Acta Medica Okayama
57巻
3号
出版者 Okayama University Medical School
開始ページ 95
終了ページ 108
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 12908007
Web of Sience KeyUT 000183816500001
JaLCDOI 10.18926/AMO/32623
フルテキストURL fulltext.pdf
著者 Furuno, Katsushi| Gomita, Yutaka| Yoshida, Toshiko| Oishi, Ryozo| Saeki, Kiyomi| Araki, Yasunori|
抄録 <p>The plasma concentration of indomethacin was measured after the rectal administration of water-soluble and fatty base suppositories in rats. The results were compared with the in vitro indomethacin release from suppositories determined by Paddle method using three different types of membranes: cellulose membrane, artificial sausage membrane and natural sausage membrane. The plasma concentrations of indomethacin during the first 4h after the rectal administration were higher in rats that received water-soluble base suppositories than in those that received fatty base types. When either a cellulose membrane or an artificial sausage membrane of cow protein was used in the Paddle method, the amount of indomethacin released from fatty base suppositories was significantly higher than that from water-soluble base ones. However, the results were reversed when a natural sausage membrane of pig colon was used. The discrepancy in the in vitro experiments using water-soluble base suppositories seemed to be due to the difference of pore size of membrane used. Careful consideration should be given to the membrane used in the Paddle method especially when this method is employed to examine the release of poorly soluble drugs like indomethacin in both water-soluble and fatty base suppositories.</p>
キーワード indomethacin suppository in vitro cellulose membrane sausage membrane in vivo bioavailability
Amo Type Article
発行日 1992-08
出版物タイトル Acta Medica Okayama
46巻
4号
出版者 Okayama University Medical School
開始ページ 223
終了ページ 231
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1442146
Web of Sience KeyUT A1992JL44200001
JaLCDOI 10.18926/AMO/32306
フルテキストURL fulltext.pdf
著者 Hashimoto, Yasuhiko| Kawasaki, Hiromu| Gomita, Yutaka|
抄録 <p>The influences of emotional changes induced by being exposed to a new environment on the pharmacokinetics of plasma drug concentration were studied in male Wistar rats. Transfer from a familiar home cage to a new home cage was considered to induce psychological (non-physical) emotional changes. First, nicorandil and zonisamide, drugs that act on the peripheral system and central nervous systems, were used, respectively. Immediately after oral administration of nicorandil (10 mg/kg) or zonisamide (50 mg/kg), the animals were transferred to new home cages. Plasma nicorandil and zonisamide concentrations were determined by high-performance liquid chromatography at 1 and 4 h after administration. Plasma nicorandil concentration in the group transferred to new home cages was significantly decreased relative to levels in the non-transferred control group. However, zonisamide concentrations were unchanged. These findings suggest that the pharmacokinetics of nicorandil, but not those of zonisamide, tend to be influenced by non-physically induced emotional changes.</p>
キーワード psychologically induced emotional changes drug plasma concentration nicorandil zonisamide
Amo Type Article
発行日 2000-02
出版物タイトル Acta Medica Okayama
54巻
1号
出版者 Okayama University Medical School
開始ページ 45
終了ページ 48
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 10709622
Web of Sience KeyUT 000085526000007
JaLCDOI 10.18926/AMO/32222
フルテキストURL fulltext.pdf
著者 Yoshida, Toshiko| Itoh, Yoshinori| Gomita, Yutaka| Oishi, Ryozo|
抄録 <p>The release of indomethacin from fatty-base suppositories, which had been stored at a low (4 degrees C) and a high (25-30 degrees C) temperature for about one month, was examined in vitro and in vivo. In the in vivo experiments, the plasma indomethacin levels after administration of suppositories stored at different temperatures were measured in conscious and anesthetized rats. In the in vitro release test using a dialysis cell method, much lower amounts of indomethacin were released from the suppositories stored at a high temperature than from those stored at a low temperature. The melting point of suppositories stored at a high temperature was higher by approximately 2 degrees C than those stored at a low temperature. In conscious rats, the plasma indomethacin levels attained after the intrarectal administration of suppositories stored at a high temperature were slightly lower than those after the animals were given suppositories stored at a low temperature, but the difference was significant only 30 min after administration. In anesthetized rats, the plasma indomethacin levels were markedly lower than those in conscious rats, and the influence of the storage temperature on the plasma indomethacin levels was clearly observed. These results suggest that in conscious rats many factors such as a locomotor hyperactivity and enhancement of gastrointestinal motility caused by the rectal administration mask the real character of suppositories. The in vitro and in vivo results show that the release of indomethacin from fatty-base suppositories stored at a high temperature is less than the release from those stored at a low temperature.</p>
キーワード indomethacin suppository quality contyol bioavailability in vitro release test
Amo Type Article
発行日 1991-02
出版物タイトル Acta Medica Okayama
45巻
1号
出版者 Okayama University Medical School
開始ページ 37
終了ページ 42
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2063694
Web of Sience KeyUT A1991FA75000005
JaLCDOI 10.18926/AMO/32186
フルテキストURL fulltext.pdf
著者 Furuno, Katsushi| Gomita, Yutaka| Araki, Yasunori| Fukuda, Tamotu|
抄録 <p>We studied the use of high-performance liquid chromatography (HPLC), using a solid phase extraction column (Bond Elut cartridge column), for the simple, rapid and sensitive determination of serum clonazepam levels in epileptic patients. Extracted aliquots were analyzed by HPLC, using a reverse phase ODS column (mu-Bondapak C18). The analytical mean recovery of clonazepam added to the blank serum averaged 99.9%. The detection limit was as high as approximately 2 ng/ml in the serum. The reproducibilities were 2.3-8.6 CV % in the within-day assay and 6.5 CV % in the between-day assay, indicating that the analysis method was effective in the determination of clonazepam serum levels. Accordingly, we suggest that the present method, using a solid phase extraction column, may be useful for the routine monitoring of clonazepam serum levels in epileptic patients.&#60;/P&#62;</p>
キーワード clonazepam serum levels epileptic patient therapeutic drug monitoring solid-phase extraction HPLC
Amo Type Article
発行日 1991-04
出版物タイトル Acta Medica Okayama
45巻
2号
出版者 Okayama University Medical School
開始ページ 123
終了ページ 127
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1867113
Web of Sience KeyUT A1991FL60800009
JaLCDOI 10.18926/AMO/32092
フルテキストURL fulltext.pdf
著者 Kitamura, Yoshihisa| Araki, Hiroaki| Nagatani, Tadashi| Takao, Katsuyuki| Shibata, Kazuhiko| Gomita, Yutaka|
抄録 <p>We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naive rats during forced-swim testing. However, chronic, 14-day forced-swim stress testing blocked the immobility-decreasing effect induced by a single administration of imipramine. When imipramine was administered for 14 days concurrently with forced-swim stress testing, immobility was shortened significantly. From the viewpoint of imipramine's effect, these findings suggest that chronic forced-swim stress testing in rats may be an effective animal model for depression.</p>
キーワード stress depression imipramine forced-swim test animal model
Amo Type Article
発行日 2004-12
出版物タイトル Acta Medica Okayama
58巻
6号
出版者 Okayama University Medical School
開始ページ 271
終了ページ 274
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 15762295
Web of Sience KeyUT 000225959100003
JaLCDOI 10.18926/AMO/32017
フルテキストURL fulltext.pdf
著者 Yamamoto, Takahiro| Araki, Hiroaki| Futagami, Koujiro| Kawasaki, Hiromu| Gomita, Yutaka|
抄録 <p>It is recognized that sustained ischemia-induced hyperactivity is related to abnormalities in dopamine function. However, it is unclear that dopaminergic neurotransmission triggers such ischemia-induced hyperactivity. Therefore, the relationship between dopaminergic neurotransmission and ischemia-induced hyperactivity was investigated in an animal model using Mongolian gerbils. When haloperidol 2 mg/kg was administered i.p. 30 min after ischemia, the ischemia-induced hyperactivity at 24 h after ischemia was blocked. General behavior was similar to that of sham-operated animals. Haloperidol at doses of 0.1 and 0.2 mg/kg had no effect on locomotor activity in sham-operated animals and decreased ischemia-induced hyperactivity when the drug was administered 24 h after ischemia; these doses did not have any effect on ischemia-induced hyperactivity when the drug was administered 30 min after ischemia. On the other hand, when the animal was confined to a small, restrictive cage for the 24 h period immediately following ischemic injury, locomotor activity at 24 h after ischemia increased. Such behavior also increased in animals when they were returned to their original more permissive cages immediately after ischemia. It is conceivable that the decrease in the level of activity was not related to ischemia-induced hyperactivity. These data suggested that the inhibition of ischemia-induced hyperactivity can be induced by complete blockage of dopaminergic receptors immediately after ischemia.</p>
キーワード ischemia hyperativity dopamine haloperidol Mongolian gerbils
Amo Type Article
発行日 2001-11
出版物タイトル Acta Medica Okayama
55巻
5号
出版者 Okayama University Medical School
開始ページ 277
終了ページ 282
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 11688950
Web of Sience KeyUT 000171635400003
JaLCDOI 10.18926/AMO/32011
フルテキストURL fulltext.pdf
著者 Futagami, Koujiro| Hirano, Naofumi| Iimori, Emiko| Motomura, Kenichi| Ide, Michiko| Kataoka, Yasuhumi| Araki, Hiroaki| Gomita, Yutaka| Oishi, Ryozo|
抄録 <p>Non-traumatic rhabdomyolysis associated with organophosphate intoxication has not been generally reported. We report here in a severe case of fenitrothion poisoning complicated by rhabdomyolysis. A 43-year-old woman ingested approximately 100 ml of fenitrothion emulsion (50%) in an attempt to commit suicide. On day 3 after admission, her creatine phosphokinase (CPK) peaked at 47,762 IU/L. She received supportive treatment included sodium bicarbonate and fluid resuscitation. However, muscarinic symptoms including excessive miosis and salivation developed on day 5 when her CPK levels decreased. The delay in cholinergic symptoms might have been due to the trihexyphenidyl she took with the antipsychotic drugs. Fortunately, the present patient recovered from the acute cholinergic crisis, and acute renal failure was prevented by early diagnosis. This is a case of organophosphate poisoning complicated by rhabdomyolysis in a psychiatric patient. The masking of acute cholinergic symptoms should be taken into consideration in such patients.</p>
キーワード fenitrothion organophosphate poisoning rhabdomyolysis psychiatric patient
Amo Type Article
発行日 2001-04
出版物タイトル Acta Medica Okayama
55巻
2号
出版者 Okayama University Medical School
開始ページ 129
終了ページ 132
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 11332199
Web of Sience KeyUT 000168195700009
JaLCDOI 10.18926/AMO/31937
フルテキストURL fulltext.pdf
著者 Kataoka, Yasufumi| Gomita, Yutaka| Fukuda, Tamotsu| Eto, Kohei| Araki, Yasunori|
抄録 <p>Methamphetamine (MA) toxicity in aggregated mice was studied by varying the number of mice and the proportion of MA treated mice kept in the same confined space. The lethality was measured 24 h after intraperitoneal injections of MA at doses ranging from 10 to 100 mg/kg. MA lethality, over a wide dose range (15 to 50 mg/kg), was higher in aggregated mice than in those maintained in isolation. The greater the proportion of MA-treated mice in aggregation was, the higher the MA lethality was. In aggregations of 10 mice, MA was lethal at lower doses than in aggregations of 5 mice. These results indicate that the lethality of MA is influenced by confinement and aggregation.</p>
キーワード methamphetamine mortality aggregation
Amo Type Article
発行日 1986-06
出版物タイトル Acta Medica Okayama
40巻
3号
出版者 Okayama University Medical School
開始ページ 121
終了ページ 126
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3739749
Web of Sience KeyUT A1986C914800001
JaLCDOI 10.18926/AMO/31908
フルテキストURL fulltext.pdf
著者 Fukuda, Tamotsu| Yoshida, Toshiko| Eto, Kohei| Gomita, Yutaka| Araki, Yasunori|
抄録 <p>This study was designed to determine the in vitro release of tegafur from a suppository and the in vivo bioavailability of tegafur in rats. Two different suppository preparations (product A-1 and product A-2) containing 750 mg of tegafur were tested for in vitro release of tegafur by the Muranishi Method (membrane diffusion method) and the partially modified paddle method (permeability through dialysis tubing). When determined by either method, the amount of tegafur released from product A-2 during the whole experimental period was significantly greater than that released from product A-1. When tested by the Muranishi method, however, the difference in the amount released during the first 10-min period was not significant. A greater bioavailability of tegafur after rectal administration was obtained by product A-2 more than product A-1. A significant correlation was observed between the in vitro release and the in vivo bioavailability. The present results indicate that there are considerable differences in physiochemical characteristics between product A-1 and product A-2.</p>
キーワード tegafur suppository in vitro release in vivo bioavailability in rats
Amo Type Article
発行日 1986-08
出版物タイトル Acta Medica Okayama
40巻
4号
出版者 Okayama University Medical School
開始ページ 195
終了ページ 200
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3094322
Web of Sience KeyUT A1986D870500003
JaLCDOI 10.18926/AMO/31766
フルテキストURL fulltext.pdf
著者 Shinozawa, Shinya| Gomita, Yutaka| Araki, Yasunori|
抄録 <p>Protective effects of clinically used drugs against adriamycin (ADM)-induced toxicity were studied in ICR mice. The control mice, which were administered 15 mg/kg of ADM twice, survived 7.48 +/- 1.99 days (mean +/- S.D.). The survival times of mice treated with the following drugs, expressed as a percent of that of the control group, were 293.6% for coenzyme Q10 (Co Q10, 2 mg/kg), 402.2% for dextran sulfate (MDS, 300 mg/kg), 121.6% for flavin adenine dinucleotide (20 mg/kg), 236.3% for adenosine triphosphate disodium (50 mg/kg), 213.7% for reduced glutathione (100 mg/kg), 121.6% for phytonadione (50 mg/kg), 155.2% for inositol nicotinate (Ino-N, 500 mg/kg), 335.5% for nicomol (1000 mg/kg), 157.5% for nicardipine (10 mg/kg) and 123.3% for dipyridamol (50 mg/kg). Anti-hyperlipemic agents such as MDS, nicomol, Ino-N and Co Q10 strongly protected against the ADM-induced toxicity, and the mice administered these drugs lived significantly longer than the control mice. The mechanism of the protective effect was discussed.</p>
キーワード adriamycin-toxicity survival time protective effect coenzyme Q10 dextran sulfate nicomol inositol nicotinate
Amo Type Article
発行日 1987-02
出版物タイトル Acta Medica Okayama
41巻
1号
出版者 Okayama University Medical School
開始ページ 11
終了ページ 17
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2436440
Web of Sience KeyUT A1987G146400002
JaLCDOI 10.18926/AMO/31736
フルテキストURL fulltext.pdf
著者 Gomita, Yutaka| Ichimaru, Yasuyuki| Ohizumi, Norihide| Yamada, Hirotoshi| Moriyama, Mimehiro| Araki, Yasunori|
抄録 <p>The anti-ulcer action of clotiazepam (a thienodiazepine derivative) was studied in mice subjected to non-physical and physical stimuli in a communication box. There were two groups of mice: the &#34;sender&#34; mice that received electric shocks on the feet and responded by squealing and jumping, and the &#34;responder&#34; mice that were affected by the senders' responses without receiving shocks on the feet. Gastric ulcers resulted in both groups. The effect of clotiazepam was compared with that of diazepam. The incidence of gastric ulcers was suppressed by clotiazepam at a dose of 3 mg/kg, per os, in &#34;responder&#34; and &#34;sender&#34; mice, and by diazepam at a dose of 1 mg/kg, per os, in &#34;responder&#34; mice. These results suggest that clotiazepam has a suppressive action against gastric ulcers produced by non-physical or physical stimuli, although its potency is slightly weaker than that of diazepam.</p>
キーワード gastric ulcer clotiazepam non-physical and physical stimuli mice
Amo Type Article
発行日 1987-12
出版物タイトル Acta Medica Okayama
41巻
6号
出版者 Okayama University Medical School
開始ページ 275
終了ページ 278
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2894110
Web of Sience KeyUT A1987L530300006
JaLCDOI 10.18926/AMO/31724
フルテキストURL fulltext.pdf
著者 Watanabe, Kazuhide| Matsuka, Naoyuki| Okazaki, Masatoshi| Hashimoto, Yasuhiko| Araki, Hiroaki| Gomita, Yutaka|
抄録 <p>The effects of immobilization stress on the pharmacokinetics of omeprazole were studied in rats. The immobilization stress for 30 or 60 min immediately after oral administration of the drug caused an increase in the time to reach the maximum concentration. However, such stress did not alter the area under the plasma concentration-time curve (AUC). When administered intravenously, the half-life during the elimination phase was significantly prolonged by 30 min of immobilization stress, but the AUC value remained unchanged. The intestinal propulsive activity was significantly decreased by immobilization stress. These findings suggest that immobilization stress reduces gastrointestinal motility. A resulting delay during the absorption phase of omeprazole occurs, although the degree of influence on overall pharmacokinetics is relatively insignificant.</p>
キーワード omeprazole pharmacokinetics stress immobilization
Amo Type Article
発行日 2002-02
出版物タイトル Acta Medica Okayama
56巻
1号
出版者 Okayama University Medical School
開始ページ 19
終了ページ 23
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 11873940
Web of Sience KeyUT 000174031300004