JaLCDOI 10.18926/AMO/30688
フルテキストURL fulltext.pdf
著者 Tanizaki, Yoshiro| Hosokawa, Masao| Goda, Yoshinori| Akagi, Katsumi| Takeyama, Hiroyasu| Kimura, Ikuro|
抄録 <p>Numerical changes in peripheral blood monocytes were examined in 125 patients with bronchial asthma using a new direct method of counting blood monocytes. The number of monocytes in non-attack stages of bronchial asthma was similar to that of healthy controls. The monocyte count observed in overall cases showed a significantly higher value both in pre-attack and attack stages than in non-attack stages. Changes in the number of monocytes in an individual spontaneous asthmatic cycle tended to increase in pre-attack stages, increase more markedly during asthma attacks, then to decrease after the attack was alleviated. Monocytes in cases with a positive test for bronchial challenge to house dust extract changed in almost the same manner as for spontaneous asthma attacks. The number of monocytes did not change during bronchospasm provoked by inhalation of acetylcholine. Exercise-induced asthma patients exhibited indefinite changes of monocytes; that is, some cases showed a significant increase in the number of monocytes related to the asthma cycle, but other cases did not show any appreciable change. These findings suggest that the number of monocytes in the peripheral blood may change in close relation to asthma attacks elicited by allergic reactions.</p>
キーワード blood monocytes nonspecific esterase staining bronchial asthma
Amo Type Article
発行日 1982-10
出版物タイトル Acta Medica Okayama
36巻
5号
出版者 Okayama University Medical School
開始ページ 341
終了ページ 348
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7180570
Web of Sience KeyUT A1982PN03500003
JaLCDOI 10.18926/AMO/30530
フルテキストURL fulltext.pdf
著者 Tanizaki, Yoshiro| Takahashi, Kiyoshi| Goda, Yoshinori| Sasaki, Yoshihede| Harada, Hiroshi| Kimura, Ikuro|
抄録 <p>Sixty-four patients with confirmed bronchial asthma were treated with HC 20-511 (Ketotifen). HC20-511 was evaluated to be very effective in 6.3%, effective in 50.0% and slightly effective in 10.9% of these patients. The appearance of reactive basophils was inhibited by HC 20-511 in 5 out of 6 cases of reaction to house dust, in all three cases with buckwheat allergy to their allergen and in 7 out of 11 cases to anti-IgE. These results confirm that HC 20-511 inhibits type I allergic reactions induced by specific allergen and IgE.</p>
キーワード bronchial asthma ketotifen basophil reactivity allergens anti-IgE
Amo Type Article
発行日 1980-12
出版物タイトル Acta Medica Okayama
34巻
6号
出版者 Okayama University Medical School
開始ページ 383
終了ページ 388
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6451144
Web of Sience KeyUT A1980KZ17800004