JaLCDOI 10.18926/AMO/30475
フルテキストURL fulltext.pdf
著者 Gomez-Vargas, Marvin| Ogawa, Norio|
抄録 <p>The use of ligand-binding methods to study neurotransmitter-receptor sites has made its impact on almost all aspects of biological pursuits including research on aging and neurodegenerative diseases. In the past, most of the research in biochemical gerontology has largely centered around changes in various neurotransmitters and enzymatic activities. The molecular basis of aging and neurodegeneration at the level of neurotransmitter-receptor interactions has been highly appreciated in the last two decades as a result of receptor binding studies. It is now possible to obtain information about the regional distribution of neurotransmitter receptors in the brain, the pharmacological and biochemical characteristics of these sites, and the functional interrelationships between different neuronal systems in normal and pathological conditions. The passage of time after maturity is accompanied by measurable physiologic decline in virtually all systems. It is the aim of this work to discuss the practical aspects of neurotransmitter and/or drug (ligand)-receptor binding studies, highlighting some examples of their applications to geriatric neuropharmacology research, with special consideration to learning impairment and memory loss in normal and in pathological aging processes.</p>
キーワード aging neurodegenerative diseases neurotransmitters receptor binding neuropharmacology
Amo Type Article
発行日 1996-08
出版物タイトル Acta Medica Okayama
50巻
4号
出版者 Okayama University Medical School
開始ページ 173
終了ページ 190
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8874579
Web of Sience KeyUT A1996VE60800001