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ID 31561
JaLCDOI
フルテキストURL
著者
Hamazaki, Heisuke Okayama University
Kato, Tomohiro Okayama University
Yunoki, Yasuhiro Okayama Univerisity
Mori, Masanobu Okayama University
Gochi, Akira Okayama University
Mimura, Hisashi Okayama University
Orita, Kunzo Okayama University
抄録

To determine whether a relationship exists between DNA ploidy and the prognosis of hepatocellular carcinoma (HCC), flow cytometric DNA analysis was performed in paraffin-embedded specimens obtained from 44 patients with HCC who underwent hepatectomy. There were 26 diploid (59%) and 18 aneuploid (41%) tumors. No correlation was shown between DNA ploidy pattern and patient age, sex, liver cirrhosis, hepatitis B virus antigen and serum alpha-fetoprotein level. The ploidy pattern had no significant correlation with the presence of vascular invasion or intrahepatic metastasis. Only Edmondson's grade was well correlated with the ploidy pattern. We noted a significant correlation between survival rates and the presence of vascular invasion or intrahepatic metastasis (p < 0.05). In contrast, no significant correlation was found between DNA ploidy pattern and the prognosis of HCC. The results of this study indicate that DNA ploidy pattern may not be a useful indicator for the prognosis of HCCs after hepatic resection, unlike the results of gastric and colon cancers.

キーワード
DNA ploidy pattern
hepatocellular carcinoma
hepatic resection
prognosis
Amo Type
Article
発行日
1993-12
出版物タイトル
Acta Medica Okayama
47巻
6号
出版者
Okayama University Medical School
開始ページ
413
終了ページ
416
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT