このエントリーをはてなブックマークに追加
ID 30379
JaLCDOI
フルテキストURL
著者
Hamazaki, Keisuke Okayama University
Gochi, Akira Okayama University
Matsubara, Nagahide Okayama University
Mori, Mazanobu Okayama University
Orita, Kunzo Okayama University
抄録

Fas antigen (ag) is a cell surface protein known to trigger apoptosis in a variety of cells upon specific antibody binding. On the other hand, Bcl-2 protein, an oncogene product located at the mitochondrial inner surface, prolongs cell survival by blocking apoptosis. In this study we examined the expression of Fas ag and bcl-2 protein in 17 cases of hepatocellular carcinoma (HCC) to determine their role on HCC. By flow cytometric analysis, mean (SD) value of the expression of Fas ag on hepatocytes derived from normal liver, diseased liver (chronic hepatitis or liver cirrhosis) and HCC was 5.8 (4.7)%, 10.3 (6.9)%, and 24.0 (18.2)%, respectively. Fas ag expression on hepatoma cells was significantly greater than normal and diseased liver cells. The expression of Bcl-2 protein in normal liver, diseased liver and HCC was 4.3 (8.5)%, 0.8 (2.5)% and 2.1 (3.4)%, respectively, and the difference was not significant. These results suggest that induction of apoptosis may be a possible therapy against HCC.

キーワード
apoptosis
Fas antigen
Bcl-2
hepatocellular carcinoma
Amo Type
Article
発行日
1995-08
出版物タイトル
Acta Medica Okayama
49巻
4号
出版者
Okayama University Medical School
開始ページ
227
終了ページ
230
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT