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ID 32683
JaLCDOI
フルテキストURL
著者
Sakagami, Kenichi Okayama University
Saito, Shinya Okayama University
Shiozaki, Shigehiro Okayama University
Takasu, Shinji Okayama University
Matsuno, Tsuyoshi Okayama University
Fujiwara, Takuzo Okayama University
Kusaka, Satoshi Okayama University
Uda, Masashi Okayama University
Matsuoka, Junji Okayama University
Naomoto, Yoshio Okayama University
Gouchi, Akira Okayama University
Hamazaki, Keisuke Okayama University
Tanaka, Shinichiro Okayama University
Orita, Kunzo Okayama University
抄録

A retrospective study was carried out in 110 cadaveric kidney transplant recipients to compare the effects of low doses of cyclosporine (CsA), azathioprine (AZP) and steroids (triple-drug therapy) with those of higher doses of steroids plus AZP (conventional immunosuppression). Graft survival rate in the triple-drug therapy was 77%, 69%, and 69% at 1, 3, and 5 years, respectively. This was significantly better than 48%, 34%, and 29% in conventional immunosuppression. The incidence of acute rejection episodes was significantly lower in the triple-drug therapy than in conventional immunosuppression (25% vs 58%). In conclusion, our study shows that triple-drug therapy using low-dose cyclosporine is the safest of the immunosuppressive regimens and provides a beneficial effect on the long-term survival of cadaveric kidney transplants.

キーワード
cadaveric kindney transplantation
cyclosporine
triple-drug therapy
Amo Type
Article
発行日
1992-02
出版物タイトル
Acta Medica Okayama
46巻
1号
出版者
Okayama University Medical School
開始ページ
53
終了ページ
56
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT