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ID 32678
JaLCDOI
フルテキストURL
著者
Sakagami, Kenichi Okayama University
Saito, Shinya Okayama University
Shiozaki, Shigehiro Okayama University
Fujiwara, Takuzo Okayama University
Haisa, Minoru Okayama University
Niguma, Takefumi Okayama University
Kusaka, Satoshi Okayama University
Uda, Masashi Okayama University
Matsuno, Tsuyoshi Okayama University
Takasu, Shinji Okayama University
Yerdel, Mehmet Ali Okayama University
Matsuoka, Junji Okayama University
Tanaka, Shinichiro Okayama University
Orita, Kunzo Okayama University
抄録

One-hundred-nine HLA-haploidentical living related renal transplants have been retrospectively analysed to compare the effect of donor-specific blood transfusion (DST) and different immunosuppressive regimens on graft survival and acute rejection. The recipients were divided into four groups according to the immunosuppressive therapy. Group 1 (n = 44): conventional therapy with posttransplant azathioprine (AZP) + methylprednisolone (MP). Group 2 (n = 25): pretransplant DST + posttransplant AZP + MP. Group 3 (n = 12): triple-drug therapy with posttransplant AZP + MP + cyclosporine (CS). Group 4 (n = 25): pretransplant DST + posttransplant AZP + MP + CS. The five-year actuarial survival rates for groups 1, 2, 3 and 4 were 48%, 73%, 79%, and 89%, respectively. The graft survival rate in group 3 was significantly (p less than 0.01) better than that in group 1. The transfusion effect was reduced, and appears as a 10% improvement in the graft survival in the cyclosporin era compared with a 25% improvement at pre-cyclosporin era. Furthermore, the incidence of the first rejection episode was decreased in recipients that received DST. The present study revealed that DST, as pretransplant conditioning has a definite impact on rejection-free long-term graft survival in HLA-haploidentical living-related kidney recipients and the most favorable outcome in such patients could be achieved by DST pretreatment in conjunction with posttransplant triple-drug therapy including cyclosporine.

キーワード
living-related kindney transplantation
donor-specific blood transfusion (DST)
cyclosporine
Amo Type
Article
発行日
1992-02
出版物タイトル
Acta Medica Okayama
46巻
1号
出版者
Okayama University Medical School
開始ページ
1
終了ページ
5
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT