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ID 32110
JaLCDOI
フルテキストURL
著者
Shinji, Toshiyuki Okayama University
Kyaw, Yi Yi Lower Myanmar
Gokan, Katsunori Okayama University
Tanaka, Yasuhito Nagoya City University
Ochi, Koji Okayama University
Kusano, Nobuchika Okayama University
Mizushima, Takaaki Okayama University
Fujioka, Shin-ichi Okayama University
Shiraha, Hidenori Okayama University
Lwin, Aye Aye Okayama University
Shiratori, Yasushi Okayama University
Mizokami, Masashi Nagoya City University
Khin, Myo Medical Research(Lower Myanmar)
Miyahara, Masayuki Okayama Red Cross Blood Center
Okada, Shigeru Okayama University
Koide, Norio Okayama University
抄録
The prevalence of hepatitis C virus (HCV) genotypes in Myanmar in comparison with the rest of Southeast Asia is not well known. Serum samples were obtained from 201 HCV antibody-positive volunteer blood donors in and around the Myanmar city of Yangon. Of these, the antibody titers of 101 samples were checked by serial dilution using HCV antibody PA test II and Terasaki microplate as a low-cost method. To compare antibody titers by this method and RNA identification, we also checked HCV-RNA using the Amplicor 2.0 test. Most high-titer groups were positive for HCV-RNA. Of the 201 samples, 110 were successfully polymerase chain reaction (PCR) amplified. Among them, 35 (31.8%) were of genotype 1, 52 (47.3%) were of genotype 3, and 23 (20.9%) were of type 6 variants, and phylogenetic analysis of these type 6 variants revealed that 3 new type 6 subgroups exist in Myanmar. We named the subgroups M6-1, M6-2, and M6-3. M6-1 and M6-2 were relatively close to types 8 and 9, respectively. M6-3, though only found in one sample, was a brand-new subgroup. These subtypes were not seen in Vietnam, where type 6 group variants are widely spread. These findings may be useful for analyzing how and when these subgroups were formed.
キーワード
hepatitis C virus(HCV)genotype
type 6 variant
Myanmar
Southeast Asia
phylogenetic analysis
Amo Type
Article
発行日
2004-06
出版物タイトル
Acta Medica Okayama
58巻
3号
出版者
Okayama University Medical School
開始ページ
135
終了ページ
142
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT