このエントリーをはてなブックマークに追加
ID 31939
JaLCDOI
フルテキストURL
著者
Sakagami, Kenichi Okayama University
Takeuchi, Hitoshi Okayama University
Tsuboi, Katsutoshi Okayama University
Matsumoto, Takamasa Okayama University
Tanaka, Kohtaro Okayama University
Ohsaki, Toshihide Okayama University
Horimi, Tadashi Okayama University
Fuchimoto, Sadanori Okayama University
Orita, Kunzo Okayama University
抄録

The survival rate of 19 patients who underwent living-related kidney transplantation after donor-specific blood transfusions (DST) was compared with that of 32 historical controls receiving transplants without DST. The graft survival rate of the DST group was 82% after two and three years. The graft survival rate of the DST group was significantly better than the 53% rate after two years obtained with the 32 historical controls (p less than 0.05). We tested sera from 16 DST-treated recipients to study the beneficial effect of DST on kidney allograft survival using the mixed lymphocyte culture (MLC) serum inhibition test. The results demonstrated that MLC inhibitory factors were induced in the serum of the recipient after completion of DST. This inhibition of MLC was observed by treatment of responder lymphocytes with serum obtained three weeks after DST plus rabbit complement. The inhibitory effect was also specific for responder cells in anti-donor MLC. Regarding the correlation with rejection episodes, these MLC inhibitory factors were often observed in the non-rejection group (p less than 0.05). The data suggest that such factors may be anti-idiotypic antibodies and be associated with prolonged graft survival.

キーワード
kidney transplantation
donor-specific blood transfusion (DST)
MLC inhibitory factors
anti-idiotypic antibody.
Amo Type
Article
発行日
1986-02
出版物タイトル
Acta Medica Okayama
40巻
1号
出版者
Okayama University Medical School
開始ページ
39
終了ページ
43
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT