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ID 32001
JaLCDOI
フルテキストURL
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著者
Takenami, Tatsuo Okayama University
Sakaguchi, Kohsaku Okayama University
Nishimura, Mamoru Okayama University
Miyake, Yasuhiro Okayama University
Miyashita, Manabi Okayama University
Terao, Masako Okayama University
Fujiwara, Akiko Okayama University
Tsuji, Takao Okayama University
抄録

This study evaluated the effects of azathioprine in combination with low-dose prednisolone in the management of patients with intractable autoimmune hepatitis. Thirteen patients with intractable autoimmune hepatitis who had an incomplete or arrested response to conventional prednisolone therapy, or who relapsed during prednisolone maintenance therapy were additionally administered 50 or 100 mg/day of azathioprine in combination with prednisolone. This regimen reliably induced complete remission in 12 of 13 patients, and these 12 remained in remission during the follow-up period with maintenance therapy of 50 mg/day of azathioprine in combination with 5 mg/day of prednisolone. The findings of the current study indicate that the azathioprine and low-dose prednisolone combined therapy may offer a satisfactory alternative therapy for patients with intractable autoimmune hepatitis who have an incomplete or arrested response to conventional prednisolone therapy, or who relapse during prednisolone maintenance therapy.

キーワード
autoimmune hepatitis
azathioprine
prednisolone
Amo Type
Article
発行日
2001-12
出版物タイトル
Acta Medica Okayama
55巻
6号
出版者
Okayama University Medical School
開始ページ
341
終了ページ
347
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT