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ID 50634
フルテキストURL
著者
Endo, Yasumasa
Tomofuji, Takaaki Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Prevent Dent
Ekuni, Daisuke
Azuma, Tetsuji
Irie, Koichiro
Kasuyama, Kenta
Morita, Manabu
抄録
Aim Trehalose, which is a disaccharide formed by a 1,1 linkage of two glucose molecules, was suggested to have a suppressive effect on bone resorption. In this study, we examined the effects of topical application of trehalose on osteoclast differentiation in a rat periodontitis model. Material and Methods Rats were divided into four groups. One group received no treatment. In the other groups, experimental periodontitis was induced by ligature placement. These rats with experimental periodontitis received topical application of pure water (vehicle group), 30 mg/ml trehalose solution (30 mg/ml trehalose group) or 60 mg/ml trehalose solution (60 mg/ml trehalose group) to the gingival sulcus respectively. Results The vehicle group showed higher numbers of polymorphonuclear leucocytes, receptor activator of nuclear factor kappa B ligand (RANKL)-positive cells and osteoclasts compared with the no treatment group respectively. Trehalose-applied groups exhibited lower numbers of these cells compared with the vehicle group. Gene expressions of tumour necrosis factor-a, RANKL and toll-like receptor 4 were suppressed by trehalose. In addition, protein expressions of RANKL inducing pathway were less activated by trehalose. Conclusion Topical application of trehalose could suppress osteoclast differentiation by inactivation of RANKL inducing pathway in the rat periodontitis model.
キーワード
animal studies
osteoclast
periodontitis
trehalose
発行日
2013-01
出版物タイトル
Journal of Clinical Periodontology
40巻
1号
出版者
Wiley-Blackwell
開始ページ
33
終了ページ
40
ISSN
0303-6979
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1111/jcpe.12032
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/50701
言語
English
論文のバージョン
author
査読
有り
DOI
Web of Sience KeyUT