JaLCDOI 10.18926/AMO/41322
フルテキストURL 64_6_367.pdf
著者 Tantular, Indah S.| Matsuoka, Hiroyuki| Kasahara, Yuichi| Pusarawati, Suhintam| Kanbe, Toshio| Tuda, Josef S. B.| Kido, Yasutoshi| Dachlan, Yoes P.| Kawamoto, Fumihiko|
抄録 We conducted a field survey of glucose-6-phosphate dehydrogenese (G6PD) deficiency in the eastern Indonesian islands, and analyzed G6PD variants molecularly. The incidence of G6PD deficiency in 5 ethnic groups (Manggarai, Bajawa, Nage-Keo, Larantuka, and Palue) on the Flores and Palue Islands was lower than that of another native group, Sikka, or a nonnative group, Riung. Molecular analysis of G6PD variants indicated that 19 cases in Sikka had a frequency distribution of G6PD variants similar to those in our previous studies, while 8 cases in Riung had a different frequency distribution of G6PD variants. On the other hand, from field surveys in another 8 ethnic groups (Timorese, Sumbanese, Savunese, Kendari, Buton, Muna, Minahasa, and Sangirese) on the islands of West Timor, Sumba, Sulawesi, Muna and Bangka, a total of 49 deficient cases were detected. Thirty-nine of these 49 cases had G6PD Vanua Lava (383T>C) of Melanesian origin. In our previous studies, many cases of G6PD Vanua Lava were found on other eastern Indonesian islands. Taken together, these findings may indicate that G6PD Vanua Lava is the most common variant in eastern Indonesian populations, except for Sikka.
キーワード Glucose-6-phosphate dehydrogenase deficiency rapid G6PD test eastern Indonesian population molecular analysis G6PD Vanua Lava
Amo Type Original Article
発行日 2010-12
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 367
終了ページ 373
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21173806
Web of Science KeyUT 000285664200003