JaLCDOI 10.18926/AMO/32904
フルテキストURL fulltext.pdf
著者 Pazarbasi, Ayfer| Kasap, Mülkiye| Güzel, Ali Írfan| Kasap, Halil| Onbasioglu, Meliz| Özbakir, Burcu| Demirkazik, Ayse| Özgünen, Fatma Tuncay| Gürtunç, Evrim|
抄録 The genetic background predisposing pregnant women to pre-eclampsia/eclampsia (PE/E) is still unknown. The aim of the current study was to investigate whether there is an association between the TNF-alpha-308 and 850 polymorphisms and PE or eclampsia. In this study, 40 cases of eclampsia, 113 cases of PE and 80 normotensive control cases were genotyped for the TNF-alpha-G-308A and C-850 polymorphisms. At position 308, the replacement of Guanine with Adenosine was denoted as TNF2. We found a significant difference between the TNF2 allele frequencies of the eclamptic, pre-eclamptic and normotensive controls. TNF2 (AA) polymorphism frequency was significantly higher among the eclamptics and pre-eclamptics (control : 5%, PE : 13.3%, E : 12.9%). A significantly different genotype distribution of C-850T polymorphism was observed between the PE/E and control groups, with the frequency of the variant TT genotype being significantly reduced in the preeclamptics (PE : 17% ; E : 17.5%) when compared with the control group (24.3%). We have demonstrated an association between TNF-alpha polymorphisms and pre-eclampsia susceptibility. However, it is not known whether C-850T polymorphism has a functional effect on the TNF-alpha gene. In addition, it was not possible to determine whether this polymorphism promotes the progression from PE to eclampsia because of no statistically significant difference between eclampsia and the controls.
キーワード TNF-alpha polymorphisms eclampsia pre-eclampsia
Amo Type Original Article
発行日 2007-06
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 153
終了ページ 160
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 17593951
Web of Science KeyUT 000247574700004