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ID 30984
JaLCDOI
フルテキストURL
著者
Lin, Qiang Hebei Medical University Fourth Hospital
Gao, Xian-Shu Hebei Medical University Fourth Hospital
Qiao, Xue-Ying Hebei Medical University Fourth Hospital
Zhou, Zhi-Guo Hebei Medical University Fourth Hospital
Zhang, Ping Hebei Medical University Fourth Hospital
Chen, Kun North China Petroleum Bureau General Hospital
Zhao, Yan-Nan North China Petroleum Bureau General Hospital
Asaumi, Junichi Okayama University Kaken ID researchmap
抄録

We defined the maximum-tolerated dose (MTD) of chemoradiotherapy (cisplatin (CDDP) with 5-fluorouracil (5-FU) and concurrent chemoradiotherapy) for Chinese patients with esophageal cancer. Twenty-one previously untreated patients with primary esophageal cancer were entered into this study. Escalating doses of CDDP with 5-FU were administered in a modified Fibonacci sequence, with concurrent conventional fractionation radiotherapy (CFR) of 60 Gy or 50 Gy. The starting doses were CDDP 37.5 mg/m2 on day 1, and 5-FU 500 mg/m2 on days 1-5, respectively. The regimen was repeated 4 times every 28 days. If no dose-limiting toxicity (DLT) was observed, the next dose level was applied. The procedures were repeated until DLT appeared. The MTD was declared to be 1 dose level below the level at which DLT appeared. DLT was grade 3 radiation-induced esophagitis at a dose level of CDDP 60 mg/m2 with 5-FU 700 mg/m2 and concurrent 60 Gy CFR. MTD was defined as CDDP 52.5 mg/m2 with 5-FU 700 mg/m2 and concurrent 50 Gy CFR. The MTD of CDDP with 5-FU and in concurrent chemoradiotherapy for Chinese patients with esophageal cancer is CDDP 52.5 mg/m2 on day 1 and 5FU 700 mg/m2 on days 1-5, repeated 4 times every 28 days, and concurrent 50 Gy CFR. Further evaluation of this regimen in a prospective phase II trial is ongoing.

キーワード
esophageal neoplasm
concurrent chemoradiotherapy
cisplatin
5-fluorouracil
dose escalation
Amo Type
Original Article
発行日
2008-02
出版物タイトル
Acta Medica Okayama
62巻
1号
出版者
Okayama University Medical School
開始ページ
37
終了ページ
44
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT