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ID 32205
JaLCDOI
フルテキストURL
著者
Shinozawa, Shinya Okayama University
Gomita, Yutakata Okayama University
Araki, Yasunori Okayama University
抄録

<P>The tissue concentration of doxorubicin (adriamycin; ADM) and its major metabolite (aglycone I) was examined in mice pretreated with alpha-tocopherol (VE) or coenzyme Q10 (CoQ). In VE-pretreated group, the concentrations of aglycone I of the liver (1, 3 and 5 h after the administration), kidney (1 and 3h) and heart (3h) were significantly higher than those in the saline group. The clinical application of VE or CoQ concomitant with anti-tumor drugs especially ADM, requires caution.

キーワード
doxorubicin
tissue concentration
?-tocopherol
coenzymeQ10
Amo Type
Article
発行日
1991-06
出版物タイトル
Acta Medica Okayama
45巻
3号
出版者
Okayama University Medical School
開始ページ
195
終了ページ
199
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT