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ID 32873
JaLCDOI
フルテキストURL
著者
Matsuoka, Hiroyuki Jichi Medical University
Thuan, Dang Thi Vinh Bao Loc General Hospital
van Thien, Huynh Bao Loc General Hospital
Kanbe, Toshio Nagoya University
Jalloh, Amadu Nagoya University
Hirai, Makoto Jichi Medical University
Arai, Meiji Jichi Medical University
Dung, Nguyen The Ho Chi Minh City Health Department
Kawamoto, Fumihiko Oita University
抄録
We conducted a survey for glucose-6-phosphate dehydrogenase (G6PD) deficiency using blood samples from male outpatients of a local hospital in southern Vietnam. Most of the samples were from the Kinh (88.9%), the largest ethnic group in Vietnam, with a small number (11.1%) coming from the K'Ho, Chauma, Nung, and Tay minorities. We detected 25 G6PD-deficient cases among 1,104 samples (2.3%), and read the open reading frame of G6PD. A novel mutation (352T>C) predicting an aminoacid change of 118Tyr>His was found in a 1-year-old Kinh boy. His G6PD activity was estimated to be less than 10% residual activity, although he did not show chronic hemolytic anemia. Thus, we categorized this variant as Class II and named it G6PD Bao Loc. In the Kinh population, G6PD Viangchan (871G>A, 1311C>T, intron 11 nt93T>C), one of the most common variants in continental Southeast Asian populations, was the highest (6/19), followed by variants originating from the Chinese such as G6PD Canton (1376G>T) (5/19), G6PD Kaiping (1388G>A) (3/19), G6PD Gaohe (95A>G) (1/19), and G6PD Quing Yuan (392G>T) (1/19). In addition, G6PD Union (1360C>T) (2/19), which originated from the Oceania, was also detected. These findings suggest that the Kinh people are derived from various ancestries from continental Southeast Asia, China, and Oceania. In contrast, all of the 5 deficient cases in the K'Ho population were G6PD Viangchan, suggesting that they were very close to Southeast Asian populations such as the Khmer in Cambodia and the Lao in Laos. It is interesting that G6PD Mahidol (487G>A), another common variant in continental Southeast Asian populations in Myanmar, Thailand, and Malaysia, has not been detected from the Vietnamese.
キーワード
Bao Loc
glucose-6-phosphate dehydrogenase defi ciency
Kinh
malaria
Vietnam
Amo Type
Original Article
発行日
2007-08
出版物タイトル
Acta Medica Okayama
61巻
4号
出版者
Okayama University Medical School
開始ページ
213
終了ページ
219
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT