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ID 31043
フルテキストURL
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著者
Sarai, Tetsuo Okayama University
Kawanishi, Koichi Okayama University
Saito, Yoshihito Okayama University
Aoi, Katsuyuki Okayama University
Nishina, Yoshiaki Okayama University
Ofuji, Tadashi Okayama University
抄録

The female patient initially showed the acquired type of total lipoatrophy at about 8 years of age. At 12 years of age, the onset of diabetes mellitus was speculated from advanced pyodermia and dedentition. At 29 years of age, glucosuria was found, and she developed proteinuria, ascites, and pretibial edema. The physical examination revealed: hepatosplenomegaly, complete absence of subcutanous fat, cutaneous xanthomas, and emaciated facies with pronounced zygomatic arches. Diabetic retinopathy was revealed in the ophthalmological examination, and nephropathy was evident in renal biopsy specimens. She also had peripheral diabetic neuropathy. No adipose tissue was found in the mesenterium under peritoneoscopy. The hepatic biopsy specimen revealed advanced portal liver cirrhosis. Laboratory findings included: hyperlipidemia, elevation of BMR without evidence of hyperthyroidism, impaired renal function, and undetected anti-insulin antibodies and anti-insulin antibodies. Endocrinological examinations revealed normal value, except for an impaired hGH response in the arginine test. C-peptide immunoreactivity was high. Her condition was fairly well controlled by 140 units of insulin injection daily.

キーワード
lipoatrophic diabetes
diabetic triopathy
hepatosplenomegaly
anti-insulin receptor antibodies
CPR
発行日
1978-08
出版物タイトル
Acta Medica Okayama
32巻
4号
出版者
Okayama University Medical School
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Amo Type
Article
Submission Path
amo/vol32/iss4/7