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ID 31129
JaLCDOI
フルテキストURL
著者
Takaki, Akinobu First Department of Internal Medicine, Okayama University Medical School Kaken ID
Sakaguchi, Kohsaku First Department of Internal Medicine, Okayama University Medical School
Ogawa, Shin First Department of Internal Medicine, Okayama University Medical School
Kawamoto, Hirofumi First Department of Internal Medicine, Okayama University Medical School
Tsuji, Takao First Department of Internal Medicine, Okayama University Medical School
抄録
We investigated the specificities and characteristics of anti-cytoskeleton antibodies in 13 anti-smooth muscle antibody (ASMA)-positive patients with chronic liver disease C (CLD-C), and compared them with those in 7 ASMA-positive patients with autoimmune hepatitis (AIH), and 6 ASMA-positive patients with chronic liver disease B (CLD-B). Anti-microfilaments (anti-MF) were found not only in 6/7 AIH patients (85.7%), but also in 8/13 CLD-C patients (61.5%) with a relatively high incidence, when compared with 1/6 CLD-B patients (16.7%), while, there was no significant difference in the incidence of anti-intermediate filaments (anti-IMF), especially anti-IMF IgM, among these patient groups. Among the patients with CLD-C, the mean levels of serum gammaglobulin and IgG in the anti-MF-positive patients were 2.46 +/- 1.03 g/dl and 3277 +/- 1089 mg/dl, respectively, which were higher than those in the anti-MF-negative patients (1.60 +/- 0.53 g/dl, 2245 +/- 610 mg/dl) and those in the patients with CLD-B (1.60 +/- 0.57 g/dl, 2192 +/- 339 mg/dl). Furthermore, 4 of the 8 anti-MF-positive patients with CLD-C satisfied the serological criteria for the diagnosis of AIH. These findings suggest that autoimmune mechanisms might be involved in the pathogenesis of anti-MF-positive CLD-C, and that anti-MF might be used as a marker.
キーワード
chronic liver disease C
autoimmune hepatitis
anti-smooth muscle antibodies
anti-cytoskeleton antibodies
anti-microfilament antibodies
Amo Type
Article
発行日
1994-06
出版物タイトル
Acta Medica Okayama
48巻
3号
出版者
Okayama University Medical School
開始ページ
143
終了ページ
149
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
Copyright© 1999 Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/3090