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ID 13690
Eprint ID
13690
フルテキストURL
Thumnail 108_71.pdf 3.45 MB
タイトル(別表記)
Prevention of peritoneal dissemination and serosal invasion of digestive tract cancer in an experimental murine model
著者
飯島 崇史 岡山大学医学部第一外科学教室
抄録
We report a novel prophylactic strategy for peritoneal dissemination and serosal invasion of digestive tract cancer in a murine model, in which the murine abdominal wall was compared to the wall of the human digestive tract. Subcutaneous injection of MH-134 cells to the abdominal wall of C3H mice induced tumors on the parietal peritoneum, and eventually caused peritoneal dissemination with time. In this model, the intraperitoneal administration of OK-432, a type of biological response modifier, after tumor implantation significantly inhibited the development of peritoneal dissemination of tumor cells. This effect was more profound in mice with tumors that extended to the peritoneal surface (designated as S1 stage). Histological examination revealed both the remarkable necrosis of tumoral tissue and the formation of a collagen fiber at the edge of the tumor. This antitumoral effect of OK-432 is thought to be mediated by both macrophages and lymphocytes migrated into the peritoneal cavity, because the administration of Carrageenan and anti-lymphocyte serum completely blocked the antitumoral effect of OK-432.
キーワード
漿膜浸潤
腹膜播種性転移
OK-432
細胞性間質反応
線維性間質反応
備考
原著
発行日
1996-06-29
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
108巻
3-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
71
終了ページ
82
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/108/3-6/108_3-6_71/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma