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ID 18773
Eprint ID
18773
フルテキストURL
Thumnail 70_221.pdf 861 KB
タイトル(別表記)
Studies on Rickettsia tsutsugamushi Ⅰ: The Investigation of Immunity by means of the Seroreaction with the Flocculation Antigen and the Particle-Absorbed-Antigen
著者
難波 一彦 岡山大学医学部陣内外科教室
抄録
The peritoneal exudate containing a large amount of rickettsiae were obtained by intraperitoneal inoculation of Rickettsia tsutsugamushi into the guinea-pigs previously injected with chlorpromazine. The antigenic substance of thus obtained peritoneal exudate was absorbed on bentonite and pine-resin particles, and was used as the agglutination antigen. The flocculation antigen was prepared from the lung of the mice intranasally inoculated with rickettsiae. By means of the seroreaction with the use of these two sorts of antigens, the author studied the influence of the difference of the amount of rickettsiae as well as the sites of inoculation on the immunity. Intracutaneous, subcutaneous, intracerebral, intraperitoneal and intranasal routes were chosen as the sites of inoculation of living rickettsiae. The intracutaneous inoculation produced the flocculation antibodies in the largest amount, the intracerebral and subcutaneous ones the nest, and they were followed by the intraperitoneal and intranasal ones. In the case of inoculation by the routes other than nose, the antibody titer rised with the lapse of time after inoculation. When inoculated by the same route, within the range of a certain amount of rickettsiae, the difference of amount gave no influence on the production of antibodies. The agglutination reaction with the use of the particle-absorbed antigen was not feasible because of its non-special reaction.
発行日
1958-01-31
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
70巻
1号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
221
終了ページ
232
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/70/1/70_1_221/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma