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ID 17055
Eprint ID
17055
フルテキストURL
Thumnail 92_567.pdf 330 KB
タイトル(別表記)
Amine metabolism in the patients with tardive dyskinesia; effects of oxypertine and hydroxyzine pamoate
著者
長尾 卓夫 岡山大学医学部神経精神医学教室
抄録
Cerebrospinal fluid HVA, MHPG, 5HIAA, cAMP and cGMP were measured in 12 chronic schizophrenic patients with tardive dyskinesia before and after the administration of oxypertine, hydroxyzine pamoate or placebo. Lumbar puncture was performed after probenecid administration. HVA levels significantly decreased and cAMP levels significantly increased after oxypertine treatment. Three of the four patients treated with oxypertine showed improvement in tardive dyskinesia. 5HIAA levels significantly decreased during hydroxyzine administration. Two of the four patients improved in tardive dyskinesia showed decrease of HVA after hydroxyzine treatment. There were no significant alterations of amine metabolites and cyclic nucleotides in the patients with placebo. Decrease of HVA may indicate the normalization of hyperdopaminergic state. It has been recognized that oxypertine is a noradrenaline depleting agent and hydroxyzine has an antiserotonic and antihistaminic properties. Noradrenaline and/or serotonin may have an effect on dopaminergic function in the central nervous system.
キーワード
tardive dyskinesia
amine metabolites
cyclic nucleotides
oxypertine
hydroxyzine pamoate
発行日
1980-06-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
92巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
567
終了ページ
573
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/92/5-6/92_5-6_567/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma