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ID 30986
JaLCDOI
フルテキストURL
著者
Ebara, Shin Okayama University
Katayama, Yoshihisa Okayama University
Tanimoto, Ryuta Okayama University
Edamura, Kohei Okayama University
Nose, Hiroyuki Okayama University
Manabe, Daisuke Okayama University
Kobayashi, Tomoko Okayama University
Kobayashi, Yasuyuki Okayama University
Kobuke, Makoto Okayama University
Takemoto, Mitsuhiro Okayama University
Saika, Takeshi Okayama University
Nasu, Yasutomo Okayama University
Kanazawa, Susumu Okayama University Kaken ID
Kumon, Hiromi Okayama University
抄録

From January 2004 to March 2007, 308 patients with clinically localized prostate cancer were treated using iodine-125 (125I) seed implantation (permanent brachytherapy) at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences. We evaluated the treatment’s effi cacy and morbidity in 300 prostate cancer patients who were followed up for more than 1 month after brachytherapy. Based on the National Comprehensive Cancer Network (NCCN) guidelines, patients with a prostate volume of less than 40 ml in transrectal ultrasound imaging were classifi ed as low or intermediate risk. The median patient age was 67 years (range 50 to 79 years), the median prostate-specific antigen (PSA) value before biopsy was 6.95 ng/ml (range 1.13 to 24.7 ng/ml), and the median prostate volume was 24.33 ml (range 9.3 to 41.76 ml). The median follow-up was 18 months (range 1 to 36 months) and the PSA levels decreased in almost all patients after brachytherapy. Although 194 of 300 patients (64.7%) complained of diffi culty in urination, pollakisuria/urgency, miction pain, and/or urinary incontinence, all of which might be associated with radiation prostatitis during the fi rst month after brachytherapy, these symptoms gradually improved. 125I seed implantation brachytherapy is safe and eff ective for localized prostate cancer within short-term follow up.

キーワード
localized prostate cancer
brachytherapy
prostate specific antigen
urinary morbidity
Amo Type
Original Article
発行日
2008-02
出版物タイトル
Acta Medica Okayama
62巻
1号
出版者
Okayama University Medical School
開始ページ
9
終了ページ
13
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT