start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=3-4
article-no=
start-page=341
end-page=349
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19850430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Epldemiological Studies of Chlordane for Termite Prevention Part 3. Effect of chlordane on oxidative phosphorylation in rat liver mitochondria
kn-title=白蟻防除処理剤クロルデンの公衆衛生学的研究　第3報　クロルデンのラット肝ミトコンドリアの酸化的リン酸化に対する作用について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to clarify the cytotoxicity of chlordane (industrial product as insecticide), the effect on oxidative phosphorylation in rat liver mitochondria was studied. The respiration rate. RCI and ADP/O ratio were inhibited by chlordane related compounds, and the degree of inhibition was in the descending order of trans-chlordane, cis-chlordane, heptachlor and heptachlor epoxide. Of the indexes indicating various respiratory activities, state 3 respiration was the most sensitively inhibited by these compounds, suggesting their energy transfer inhibition. However, electron transport was also inhibited by high concentrations of chlordane constituents. The inhibitory effect of the chlordane constituents on respiratory activity varied depending on the species of respiratory substrate, suggesting site specificity of these compounds. Trans-chlordane, cis-chlordane and heptachlor stimulated Mg(2+) ATPase activity and inhibited DNP-stimulated ATPase activity. Heptachlorepoxide, a metabolic product of heptachlor, has less effect on mitochondria than heptachlor.
en-copyright=
kn-copyright=

en-aut-name=NoguchiNobuyuki
en-aut-sei=Noguchi
en-aut-mei=Nobuyuki
kn-aut-name=野口信行
kn-aut-sei=野口
kn-aut-mei=信行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=クロルデン
kn-keyword=クロルデン
en-keyword=ミトコンドリア
kn-keyword=ミトコンドリア
en-keyword=酸化的リン酸化
kn-keyword=酸化的リン酸化
END

start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=3-4
article-no=
start-page=327
end-page=339
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19850430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Epidemiological studies of chlordane for termite prevention Part 2. Metabolism of chlordane in exposed rats
kn-title=白蟻防除処理剤クロルデンの公衆衛生学的研究　第2報　クロルデン暴露ラットの生体内運命について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=I exposed rats to chlordane (industrial product) and measured the concentration of chlordane in various tissues of rats over time. Exposure to chlordane for 3.5 hours appoximated the exposure to chlordane in a house a hundred days after treatment for termites. However, chlordane and metabolites were detected in all the tissues of rats. The concentration of chlordane in various tissues showed highest level one hour after exposure. After that, heptachlor, γ-chlordane, trans-chlordane and cis-chlordane were excreted fast, while trans-noachlor and cis-nonachlor were excreted extremely slowly. The metabolites of chlordane (heptachlorepoxide and oxichlordane) showed the highest level one after exposure in the various tissues, and after that they were excreted slowly. Chlordane had the highest level in the adipose tissue and the second highest level in the liver, kidney, lung, pectoral muscle and heart. In the spleen and brain it showed a relatively low level. The lowest level was in the blood. As for Biological Harf Life (B.H.L.), the number of days in the secondary excretion in the adipose tissue of chlordane excreted late was as follows: trans-nonachlor 38.5 days, cis-nonachlor 16.5 days, and metabolites 16.9 days. It is suggested that the chronic toxicity of trans-nonachlor, cis-nonachlor and metabolites should be investigated in future.
en-copyright=
kn-copyright=

en-aut-name=NoguchiNobuyuki
en-aut-sei=Noguchi
en-aut-mei=Nobuyuki
kn-aut-name=野口信行
kn-aut-sei=野口
kn-aut-mei=信行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=クロルデン
kn-keyword=クロルデン
en-keyword=暴露ラット
kn-keyword=暴露ラット
en-keyword=生体内運命
kn-keyword=生体内運命
en-keyword=生物学的半減期
kn-keyword=生物学的半減期
END

start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=3-4
article-no=
start-page=315
end-page=326
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19850430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Epidemiological Studies of Chlordane for Termite Prevention Part 1. Chlordane residues of houses treated for termites and results of blood tests of pest control operators
kn-title=白蟻防除処理剤クロルデンの公衆衛生学的研究　第1報　白蟻防除処理家屋におけるクロルデン残留量と作業者の血液検査成績について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Chlordane is widely used as an anti-termite pesticide for wooden houses. Pest control operators as well as the residents of chlordane treated houses might become sick through the exposure to the chemical. The chlordane concentration in the air and soil after the treatment was examined. The Chlordane concentration in the blood of pest control operators was also examined. A 40% emulsion of chlordane was used together wigh a 2% pestrolum emulsion as a sprinkling pesticide. Its constituents as determined by GC-ECD were in the descending order of trans-chloirdane, trans-nonachlor, cis-chlordane, γ-chlordene, heptachlor and cis-nonachlor. The Chlordane concentration in the air was the highest immediately after the treatment, and decreased gradually with the lapse of time. Heptachlor was the largest, and cis-nonachlor the smallest constituent of chlordane detected in the air. On the contrary, cis-nonachlor was the largest, and heptachlor the smallest contituent in the soil. This suggests that the exposure dose of heptachlor may be extreme. Heptachlorepoxide and oxychlordane as metabolites, and trans-nonachlor and cis-nonachlor were detected in the blood of pest control operators. The C.P.K. value increased in their blood.
en-copyright=
kn-copyright=

en-aut-name=NoguchiNobuyuki
en-aut-sei=Noguchi
en-aut-mei=Nobuyuki
kn-aut-name=野口信行
kn-aut-sei=野口
kn-aut-mei=信行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=クロルデン
kn-keyword=クロルデン
en-keyword=大気中
kn-keyword=大気中
en-keyword=土壌中濃度
kn-keyword=土壌中濃度
en-keyword=血液検査
kn-keyword=血液検査
END

start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=3-4
article-no=
start-page=191
end-page=199
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19850430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on chlorinated hydrocarbons as pollutants Part 4. Trihalomethane formation during water disinfection by chlorine
kn-title=環境汚染物質(―塩素化炭化水素―)に関する研究　第4報　塩素処理過程におけるトリハロメタンの生成(―特にプール水―)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The trihalomethane (THM) levels were examined in discharged water from a human waste treatment plant, in tap water and in the water of swimming pools. The amounts of residual free chlorine, consumed KMnO(4) and coliform in the water of swimming pools were also determined. A significant increase in the THM content was found in the water of swimming pools, where the proportion of chloroform against total THM was remarkably high. The high proportion of THM may have resulted from THM formation due to repeated disinfection by chlorine. The trihalomethane content increases in accordance with residual free chlorine in the water of swimming pools. When chlorine was under the standard level (0.4mg/l), some pools had high levels of coliform, but few had high concentrations of THM. However, when chlorine was over the standard level no pools had unsatisfactory levels of coliform, although more pools had high concentrations of THM.
en-copyright=
kn-copyright=

en-aut-name=NoguchiNobuyuki
en-aut-sei=Noguchi
en-aut-mei=Nobuyuki
kn-aut-name=野口信行
kn-aut-sei=野口
kn-aut-mei=信行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=プール水
kn-keyword=プール水
en-keyword=トリハロメタン
kn-keyword=トリハロメタン
en-keyword=遊離残留塩素
kn-keyword=遊離残留塩素
en-keyword=大腸菌群
kn-keyword=大腸菌群
END