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ID 16783
Eprint ID
16783
フルテキストURL
Thumnail 94_431.pdf 390 KB
タイトル(別表記)
Studies on Patients with Sarcoidosis Part Ⅱ. Monocyte Function in Sarcoidosis Patients
著者
近藤 昭 岡山大学医学部第2内科教室
抄録
Functions of peripheral blood monocytes in 13 patients with sarcoidosis were studied and compared to normal individuals. The mean absolute number of monocytes was 277±121/cmm(M±SD) in sarcoidosis patients and 299±144/cmm in controls. However, there was no significant difference between the two groups. Lysosomal enzyme activity of monocytes was histochemically determined by ability of staining to beta-galactosidase. The mean percentage of beta-galactosidase positive monocytes was 35.8±16.9 in sarcoidosis patients and 33.7±12.1 in controls. There was no significant difference between the two groups. Monocyte chemotactic response was measured in vitro by Boyden's millipore technique-using zymosan activated human serum as chemoattractant. Chemotactic response was significantly reduced in sarcoidosis patients(28.2±7.0) compared with controls (34.8±8.0). Ability of monocyte to phagocytize the complement coated zymosan was also significantly lower in sarcoidosis patients(49.2±24.1) compared with controls (84.1±9.4). Monocyte-mediated cytotoxicity was tested by the inhibition of (3)H-thymidine uptake by two tumor cell lines. The growth-inhibitory activity was 87.0±8.6 in sarcoidosis patients and 85.5±8.0 in controls using human squamous lung cancer cell line(EBC-1) for the target cell, and 47.5±14.0 and 46.4±11.8 respectively using Hella cell. There was no significant difference between the two groups using either target cell.
キーワード
Sarcoidosis
Monocyte
発行日
1982-06-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
94巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
431
終了ページ
438
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/94/5-6/94_5-6_431/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma